Bafilomycin B1
Bafilomycin B1 structure
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Common Name | Bafilomycin B1 | ||
|---|---|---|---|---|
| CAS Number | 88899-56-3 | Molecular Weight | 815.986 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 939.4±65.0 °C at 760 mmHg | |
| Molecular Formula | C44H65NO13 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 521.9±34.3 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells.
Proc. Natl. Acad. Sci. U. S. A. 85 , 7972, (1988) Various membrane ATPases have been tested for their sensitivity to bafilomycin A1, a macrolide antibiotic. F1F0 ATPases from bacteria and mitochondria are not affected by this antibiotic. In contrast, E1E2 ATPases--e.g., the K+-dependent (Kdp) ATPase from Esc... |
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Inhibition of the accumulation of lipid droplets in macrophage J774 by bafilomycin B1 and destruxin E.
Biochim. Biophys. Acta 1126(1) , 41-8, (1992) Two microbial metabolites, bafilomycin B1 and destruxin E, have been found to inhibit significantly the oxidized low density lipoprotein (LDL)-induced accumulation of lipid droplets at 3 nM and 0.5 microM, respectively, in macrophage J774. The incorporation o... |
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The plecomacrolide vacuolar-ATPase inhibitor bafilomycin, alters insulin signaling in MIN6 beta-cells.
Cell Biol. Toxicol. 22(3) , 169-81, (2006) Inhibition of endosomal acidification disturbs insulin signaling in both liver and adipose cells. In this study we used MIN6 beta cells to determine whether bafilomycin, a potent inhibitor of the proton-translocating vacuolar ATPase, disrupts insulin signalin... |
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Vesicular calcium transport shapes rapid acetylcholine secretion.
J. Mol. Neurosci. 30(1-2) , 41-4, (2006) Rapid secretion relies on the occurrence of spike-like Ca2+ transients in active zones (Llinás et al., 1992; Yazejian et al., 2000; Dunant and Bloc, 2003). Presynaptic Ca2+ nanodomains are to be restricted both in time and in space as to assure rapid onset an... |
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Changes in Aspergillus nidulans gene expression induced by bafilomycin, a Streptomyces-produced antibiotic.
Microbiology 145 ( Pt 5) , 1115-22, (1999) In natural environments bacteria and filamentous fungi often compete for the same resources. Consequently, production of antibiotic secondary metabolites and defence mechanisms against these compounds have evolved in these organisms. An experimental model has... |
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Semisynthetic derivatives of concanamycin A and C, as inhibitors of V- and P-type ATPases: structure-activity investigations and developments of photoaffinity probes.
Biochemistry 40(9) , 2816-25, (2001) V-type ATPases are inhibited by the plecomacrolides bafilomycin and concanamycin, which exert their inhibitory potential at nanomolar concentrations. In addition, some P-type ATPases are inhibited at micromolar concentrations. We initiated intensive structure... |
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Association of a 19- and a 21-kDa GTP-binding protein to pancreatic microsomal vesicles is regulated by the intravesicular pH established by a vacuolar-type H(+)-ATPase.
J. Membr. Biol. 125(3) , 231-41, (1992) Evidence suggests that certain ras-related small molecular weight GTP-binding proteins (smg-proteins) are involved in intracellular membrane trafficking and vesicle fusion. We have previously shown that intravesicular acidification due to a vacuolar-type H(+)... |
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Biosynthetic investigations of the V-type ATPase inhibitors bafilomycin A1, B1 and concanamycin A.
J. Antibiot. 57(10) , 655-61, (2004) The plecomacrolides bafilomycin A1 and B1 (1, 2) and concanamycin A (3), produced by different Streptomyces species, show a unique macrolactone structure with characteristic side chains and exhibit striking biological activities including distinct V-type ATPa... |
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Streptomyces halstedii K122 produces the antifungal compounds bafilomycin B1 and C1.
Can. J. Microbiol. 46(8) , 753-8, (2000) Streptomyces halstedii K122 was previously found to produce antifungal compounds on solid substrates that inhibit radial growth of fungi among Ascomycetes, Basidiomycetes, Deuteromycetes, Oomycetes, and Zygomycetes, and strongly affected hyphal branching and ... |
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Characterization of the bafilomycin biosynthetic gene cluster from Streptomyces lohii.
ChemBioChem. 14(3) , 301-6, (2013) New hope for old bones: The plecomacrolide bafilomycin has been explored for decades as an anti-osteoporotic. However, its structural complexity has limited the synthesis of analogues. The cloning of the bafilomycin biosynthetic gene cluster from the environm... |