Quinolinic acid

Names

[ CAS No. ]:
89-00-9

[ Name ]:
Quinolinic acid

[Synonym ]:
2,3-Pyridinedicarboxylic acid
MFCD00006295
EINECS 201-874-8
Quinolinic acid
UNII-F6F0HK1URN
T6NJ BVQ CVQ
Pyridine-2,3-dicarboxylic acid

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
425.0±30.0 °C at 760 mmHg

[ Melting Point ]:
188-190ºC

[ Molecular Formula ]:
C₇H₅NO₄

[ Molecular Weight ]:
167.119

[ Flash Point ]:
210.9±24.6 °C

[ Exact Mass ]:
167.021851

[ PSA ]:
87.49000

[ LogP ]:
-1.44

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.628

[ Storage condition ]:
Store at RT

[ Water Solubility ]:
0.55 g/100 mL

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: US7967250

CHEMICAL NAME :: 2,3-Pyridinedicarboxylic acid

CAS REGISTRY NUMBER :: 89-00-9

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C7-H5-N-O4

MOLECULAR WEIGHT :: 167.13

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 1050 mg/kg

SEX/DURATION :: female 1-21 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - biochemical and metabolic

REFERENCE :: ETPAEK Experimental and Toxicologic Pathology. (Gustav Fischer Verlag Jena, Postfach 100537, D-07705 Jena, Germany) V.44- 1992- Volume(issue)/page/year: 46,323,1994

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H319-H335

[ Precautionary Statements ]:
P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
US7967250

[ HS Code ]:
29333999

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

leucoline
2-Picolinic acid
Carbon dioxide
Diethyl pyridine-2,3-dicarboxylate
8-Quinolinesulfonyl chloride
8-Hydroxyquinoline
3-Hydroxyanthranilic acid
Quinaldine
6-Methylquinoline
8-Methylquinoline

DownStream

Pyrido[2,3-d]pyridazine-5,8-diol
Methyl 3-aminopyridine-2-carboxylate
Nicotinic acid mononucleotide
3,4-Pyridinedicarboximide
Nipecotic acid
cis-2,3-piperidinedicarboxylic acid
Pipecolic acid
2,3-Pyridinedicarboxylicacid, copper(2+) salt (1:1)
Nicotinic acid
Nicotinamide

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

The CB₁ cannabinoid receptor signals striatal neuroprotection via a PI3K/Akt/mTORC1/BDNF pathway.

Cell Death Differ. 22 , 1618-29, (2015)

The CB1 cannabinoid receptor, the main molecular target of endocannabinoids and cannabis active components, is the most abundant G protein-coupled receptor in the mammalian brain. In particular, the C...

Activation of the kynurenine pathway and increased production of the excitotoxin quinolinic acid following traumatic brain injury in humans.

J. Neuroinflammation 12 , 110, (2015)

During inflammation, the kynurenine pathway (KP) metabolises the essential amino acid tryptophan (TRP) potentially contributing to excitotoxicity via the release of quinolinic acid (QUIN) and 3-hydrox...

Age-related reference values for urinary organic acids in a healthy Turkish pediatric population.

Clin. Chem. 40(6) , 862-6, (1994)

Organic acid concentrations were quantified by gas chromatography and the individual acids identified by mass spectrometry in urine specimens from a healthy Turkish pediatric population of ages 2 days...