Quinolinic acid
Quinolinic acid structure
|
Common Name | Quinolinic acid | ||
|---|---|---|---|---|
| CAS Number | 89-00-9 | Molecular Weight | 167.119 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 425.0±30.0 °C at 760 mmHg | |
| Molecular Formula | C7H5NO4 | Melting Point | 188-190ºC | |
| MSDS | Chinese USA | Flash Point | 210.9±24.6 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of Quinolinic acidQuinolinic acid is an endogenous N-methyl-D-aspartate receptor agonist synthesized from L-tryptophan via the kynurenine pathway and thereby has the potential of mediating N-methyl-D-aspartate neuronal damage and dysfunction. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | quinolinic acid |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Quinolinic acid is an endogenous N-methyl-D-aspartate receptor agonist synthesized from L-tryptophan via the kynurenine pathway and thereby has the potential of mediating N-methyl-D-aspartate neuronal damage and dysfunction. |
|---|---|
| Related Catalog | |
| Target |
Human Endogenous Metabolite |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 425.0±30.0 °C at 760 mmHg |
| Melting Point | 188-190ºC |
| Molecular Formula | C7H5NO4 |
| Molecular Weight | 167.119 |
| Flash Point | 210.9±24.6 °C |
| Exact Mass | 167.021851 |
| PSA | 87.49000 |
| LogP | -1.44 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.628 |
| InChIKey | GJAWHXHKYYXBSV-UHFFFAOYSA-N |
| SMILES | O=C(O)c1cccnc1C(=O)O |
| Storage condition | Store at RT |
| Water Solubility | 0.55 g/100 mL |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H319-H335 |
| Precautionary Statements | P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi:Irritant |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | US7967250 |
| HS Code | 29333999 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 10 | |
|---|---|
| DownStream 10 | |
CAS#:91-22-5
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CAS#:611-32-5![Pyrido[2,3-d]pyridazine-5,8-diol structure](https://image.chemsrc.com/caspic/118/4430-77-7.png)
CAS#:4430-77-7
CAS#:36052-27-4
CAS#:321-02-8
CAS#:4664-00-0
CAS#:498-95-3
CAS#:82949-15-3
CAS#:4043-87-2
CAS#:18970-62-2
CAS#:59-67-6
CAS#:98-92-0This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2933399090 |
|---|---|
| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
This table lists relevant public references with title, journal and publication metadata for this compound.
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The CB₁ cannabinoid receptor signals striatal neuroprotection via a PI3K/Akt/mTORC1/BDNF pathway.
Cell Death Differ. 22 , 1618-29, (2015) The CB1 cannabinoid receptor, the main molecular target of endocannabinoids and cannabis active components, is the most abundant G protein-coupled receptor in the mammalian brain. In particular, the C... |
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Activation of the kynurenine pathway and increased production of the excitotoxin quinolinic acid following traumatic brain injury in humans.
J. Neuroinflammation 12 , 110, (2015) During inflammation, the kynurenine pathway (KP) metabolises the essential amino acid tryptophan (TRP) potentially contributing to excitotoxicity via the release of quinolinic acid (QUIN) and 3-hydrox... |
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Age-related reference values for urinary organic acids in a healthy Turkish pediatric population.
Clin. Chem. 40(6) , 862-6, (1994) Organic acid concentrations were quantified by gas chromatography and the individual acids identified by mass spectrometry in urine specimens from a healthy Turkish pediatric population of ages 2 days... |
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| 2,3-Pyridinedicarboxylic acid |
| MFCD00006295 |
| EINECS 201-874-8 |
| Quinolinic acid |
| UNII-F6F0HK1URN |
| T6NJ BVQ CVQ |
| Pyridine-2,3-dicarboxylic acid |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the SMILES notation of quinolinic acid? |
| A: SMILES notation of quinolinic acid is O=C(O)c1cccnc1C(=O)O. |
| Q: How is the water solubility of quinolinic acid? |
| A: Water solubility of quinolinic acid: 0.55 g/100 mL. |
| Q: What is the polar surface area (PSA) of quinolinic acid? |
| A: Polar surface area (PSA) of quinolinic acid is 87.49000. |
| Q: What English synonyms does quinolinic acid have? |
| A: English synonyms of quinolinic acid: 2,3-Pyridinedicarboxylic acid, MFCD00006295, EINECS 201-874-8, Quinolinic acid, UNII-F6F0HK1URN, T6NJ BVQ CVQ, Pyridine-2,3-dicarboxylic acid. |
| Q: What is the molecular weight of quinolinic acid? |
| A: Molecular weight of quinolinic acid is 167.119. |
| Q: What are the downstream products of quinolinic acid? |
| A: Related downstream products(CAS) of quinolinic acid: 4430-77-7;36052-27-4;321-02-8;4664-00-0;498-95-3;82949-15-3;4043-87-2;18970-62-2;59-67-6;98-92-0. |
| Q: What is the boiling point of quinolinic acid? |
| A: Boiling point of quinolinic acid is 425.0±30.0 °C at 760 mmHg. |
| Q: What are the storage conditions for quinolinic acid? |
| A: Storage conditions for quinolinic acid: Store at RT. |
| Q: What is the melting point of quinolinic acid? |
| A: Melting point of quinolinic acid is 188-190ºC. |
| Q: What is the LogP of quinolinic acid? |
| A: LogP of quinolinic acid is -1.44. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |
| Henan Tianfu Chemical Co., Ltd. |
| Zhongshan Xingrui Chemical Co. , Ltd. |
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- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Quinolinic acid
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- Purity: 98.0%
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- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: Quinolinic acid
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
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- Henan Tianfu Chemical Co., Ltd.
- China
- Product Name: quinolinic acid
- Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
- Purity: 99.0%
- Delivery: Inquiry
- Contact: Anson
- Email: info@tianfuchem.com
- Zhongshan Xingrui Chemical Co. , Ltd.
- China
- Product Name: Quinolinic acid
- Price: ￥Inquiry/25kg
- Purity: 99.0%
- Delivery: Inquiry
- Contact: Wang Jie
- Email: 3096638339@qq.com
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