Quinolinic acid

Modify Date: 2024-01-01 17:33:43

Quinolinic acid Structure
Quinolinic acid structure
 Common Name Quinolinic acid
CAS Number 89-00-9 Molecular Weight 167.119
Density 1.6±0.1 g/cm3 Boiling Point 425.0±30.0 °C at 760 mmHg
Molecular Formula C7H5NO4 Melting Point 188-190ºC
MSDS Chinese USA Flash Point 210.9±24.6 °C
Symbol GHS07
GHS07		 Signal Word Warning

 Use of Quinolinic acid


Quinolinic acid is an endogenous N-methyl-D-aspartate receptor agonist synthesized from L-tryptophan via the kynurenine pathway and thereby has the potential of mediating N-methyl-D-aspartate neuronal damage and dysfunction.

 Names

Name quinolinic acid
Synonym More Synonyms

 Quinolinic acid Biological Activity

Description Quinolinic acid is an endogenous N-methyl-D-aspartate receptor agonist synthesized from L-tryptophan via the kynurenine pathway and thereby has the potential of mediating N-methyl-D-aspartate neuronal damage and dysfunction.
Related Catalog
Target

Human Endogenous Metabolite

References

[1]. Heyes MP, et al. Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease. Brain. 1992 Oct;115 ( Pt 5):1249-73.

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Boiling Point 425.0±30.0 °C at 760 mmHg
Melting Point 188-190ºC
Molecular Formula C7H5NO4
Molecular Weight 167.119
Flash Point 210.9±24.6 °C
Exact Mass 167.021851
PSA 87.49000
LogP -1.44
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.628
Storage condition Store at RT
Water Solubility 0.55 g/100 mL

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
US7967250
CHEMICAL NAME :
2,3-Pyridinedicarboxylic acid
CAS REGISTRY NUMBER :
89-00-9
LAST UPDATED :
199701
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C7-H5-N-O4
MOLECULAR WEIGHT :
167.13

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
1050 mg/kg
SEX/DURATION :
female 1-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
ETPAEK Experimental and Toxicologic Pathology. (Gustav Fischer Verlag Jena, Postfach 100537, D-07705 Jena, Germany) V.44- 1992- Volume(issue)/page/year: 46,323,1994

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H319-H335
Precautionary Statements P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant
Risk Phrases R36/37/38
Safety Phrases S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS US7967250
HS Code 29333999

 Synthetic Route

 Customs

HS Code 2933399090
Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles110

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 Synonyms

2,3-Pyridinedicarboxylic acid
MFCD00006295
EINECS 201-874-8
Quinolinic acid
UNII-F6F0HK1URN
T6NJ BVQ CVQ
Pyridine-2,3-dicarboxylic acid
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