4-Chloro-2-nitroaniline
Suppliers
Names
[ CAS No. ]:
89-63-4
[ Name ]:
4-Chloro-2-nitroaniline
[Synonym ]:
4-chloro-2-nitro-phenylamine
4-chloro-2-nitro-aniline
Red Salt Ciba VI
2-Nitro-4-chloroaniline
Benzenamine,4-chloro-2-nitro
Devol Red Salt F
Red Base Ciba VI
ZR DG BNW
EINECS 201-925-4
1-amino-2-nitro-4-chlorobenzene
MFCD00007836
Benzenamine, 4-chloro-2-nitro-
Aniline,4-chloro-2-nitro
4-Chloro-2-nitroaniline
Red Salt Nbgl
4-Chloro-2-nitrobenzenamine
Devol Red F
Red Base Irga VI
azoamine red 2C
Chemical & Physical Properties
[ Density]:
1.5±0.1 g/cm3
[ Boiling Point ]:
308.8±22.0 °C at 760 mmHg
[ Melting Point ]:
117-119 °C(lit.)
[ Molecular Formula ]:
C6H5ClN2O2
[ Molecular Weight ]:
172.569
[ Flash Point ]:
140.5±22.3 °C
[ Exact Mass ]:
172.003952
[ PSA ]:
71.84000
[ LogP ]:
2.74
[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C
[ Index of Refraction ]:
1.646
[ Water Solubility ]:
INSOLUBLE
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- BX1575000
- CHEMICAL NAME :
- Aniline, 4-chloro-2-nitro-
- CAS REGISTRY NUMBER :
- 89-63-4
- BEILSTEIN REFERENCE NO. :
- 0512436
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 14
- MOLECULAR FORMULA :
- C6-H5-Cl-N2-O2
- MOLECULAR WEIGHT :
- 172.58
- WISWESSER LINE NOTATION :
- ZR DG BNW
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 400 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 63 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 3 gm/kg
- TOXIC EFFECTS :
- Behavioral - general anesthetic
MUTATION DATA
- TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Rodent - hamster Ovary
- DOSE/DURATION :
- 20 mg/L
- REFERENCE :
- EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 10(Suppl 10),1,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X8936 No. of Facilities: 96 (estimated) No. of Industries: 2 No. of Occupations: 5 No. of Employees: 17827 (estimated) No. of Female Employees: 16443 (estimated)
Safety Information
[ Symbol ]:
GHS06, GHS08, GHS09
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H300 + H310 + H330-H373-H411
[ Precautionary Statements ]:
P260-P264-P273-P280-P284-P301 + P310
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
[ Hazard Codes ]:
T+:Verytoxic;N:Dangerous for the environment;
[ Risk Phrases ]:
R26/27/28;R33;R51/53
[ Safety Phrases ]:
S28-S36/37-S45-S61-S28A
[ RIDADR ]:
UN 2237 6.1/PG 3
[ WGK Germany ]:
2
[ RTECS ]:
BX1575000
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1
[ HS Code ]:
29214210
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2921420090
[ Summary ]:
HS:2921420090 aniline derivatives and their salts VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%
Articles
Med. Lav. 82(3) , 253-60, (1991)
The toxicity of 4-chloro-2-nitroaniline (4C2NA) and 2-chloro-4-nitroaniline (2C4NA) was investigated on isolated rat hepatocytes following 1-3 hours of exposure to 0.2 and/or 2 mM of these xenobiotics...
J. Toxicol. Environ. Health A 12(2-3) , 267-82, (1983)
The disposition and metabolism of 14C-labeled 4-chloro-2-nitroaniline (CNA) was studied in male F344 rats following oral or intravenous (iv) administration. The gastrointestinal absorption of CNA was ...