4-Chloro-2-nitroaniline

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Names

[ CAS No. ]:
89-63-4

[ Name ]:
4-Chloro-2-nitroaniline

[Synonym ]:
4-chloro-2-nitro-phenylamine
4-chloro-2-nitro-aniline
Red Salt Ciba VI
2-Nitro-4-chloroaniline
Benzenamine,4-chloro-2-nitro
Devol Red Salt F
Red Base Ciba VI
ZR DG BNW
EINECS 201-925-4
1-amino-2-nitro-4-chlorobenzene
MFCD00007836
Benzenamine, 4-chloro-2-nitro-
Aniline,4-chloro-2-nitro
4-Chloro-2-nitroaniline
Red Salt Nbgl
4-Chloro-2-nitrobenzenamine
Devol Red F
Red Base Irga VI
azoamine red 2C

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
308.8±22.0 °C at 760 mmHg

[ Melting Point ]:
117-119 °C(lit.)

[ Molecular Formula ]:
C₆H₅ClN₂O₂

[ Molecular Weight ]:
172.569

[ Flash Point ]:
140.5±22.3 °C

[ Exact Mass ]:
172.003952

[ PSA ]:
71.84000

[ LogP ]:
2.74

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.646

[ Water Solubility ]:
INSOLUBLE

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BX1575000

CHEMICAL NAME :: Aniline, 4-chloro-2-nitro-

CAS REGISTRY NUMBER :: 89-63-4

BEILSTEIN REFERENCE NO. :: 0512436

LAST UPDATED :: 199710

DATA ITEMS CITED :: 14

MOLECULAR FORMULA :: C6-H5-Cl-N2-O2

MOLECULAR WEIGHT :: 172.58

WISWESSER LINE NOTATION :: ZR DG BNW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 63 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Behavioral - general anesthetic

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 20 mg/L

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 10(Suppl 10),1,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X8936 No. of Facilities: 96 (estimated) No. of Industries: 2 No. of Occupations: 5 No. of Employees: 17827 (estimated) No. of Female Employees: 16443 (estimated)

Safety Information

[ Symbol ]:

GHS06, GHS08, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H300 + H310 + H330-H373-H411

[ Precautionary Statements ]:
P260-P264-P273-P280-P284-P301 + P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
T+:Verytoxic;N:Dangerous for the environment;

[ Risk Phrases ]:
R26/27/28;R33;R51/53

[ Safety Phrases ]:
S28-S36/37-S45-S61-S28A

[ RIDADR ]:
UN 2237 6.1/PG 3

[ WGK Germany ]:
2

[ RTECS ]:
BX1575000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

[ HS Code ]:
29214210

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

4-Chloroaniline
3-Nitrochlorobenzene
2-Nitroaniline
Benzene,1-azido-2-nitro-
N-(4-Chloro-2-nitrophenyl)acetamide
4-Chloro-N-(2-hydroxyethyl)-2-nitroaniline
Methanesulfonyl chloride
4-Chloroacetanilide
1,4-Dichloro-2-nitrobenzene
Benzene, 1-azido-4-chloro-2-nitro

DownStream

3-chloro-7,9,10-triazabicyclo[4.4.0]deca-2,4,7,9,11-pentaen-8-amine
4-Chlorosalicylic acid
4-Chloro-2-nitrobenzonitrile
6-Chloro-L-tryptophan
6-Chloro-8-quinolinamine
3-chloro-9-oxido-8-oxa-7-aza-9-azoniabicyclo[4.3.0]nona-2,4,6,9-tetraene
4-Chloro-2,6-dinitroaniline
5-(4-chloro-2-nitrophenyl)furan-2-carbaldehyde
1-Bromo-4-chloro-2-nitrobenzene
6-CHLOROQUINOXALINE

Customs

[ HS Code ]: 2921420090

[ Summary ]:
HS:2921420090 aniline derivatives and their salts VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

[Toxicity of 4-chloro-2-nitroaniline and 2-chloro-4-nitroaniline to isolated rat hepatocytes].

Med. Lav. 82(3) , 253-60, (1991)

The toxicity of 4-chloro-2-nitroaniline (4C2NA) and 2-chloro-4-nitroaniline (2C4NA) was investigated on isolated rat hepatocytes following 1-3 hours of exposure to 0.2 and/or 2 mM of these xenobiotics...

Disposition and metabolism of 4-chloro-2-nitroaniline in the male F344 rat.

J. Toxicol. Environ. Health A 12(2-3) , 267-82, (1983)

The disposition and metabolism of 14C-labeled 4-chloro-2-nitroaniline (CNA) was studied in male F344 rats following oral or intravenous (iv) administration. The gastrointestinal absorption of CNA was ...