Dehydronitrendipine

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Names

[ Name ]:
Dehydronitrendipine

[Synonym ]:
Nitrendipine M (dehydro)
Ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate
2,6-dimethyl-3-methoxycarbonyl-4-(m-nitrophenyl)-5-ethoxycarbonylpyridine
3,5-Pyridinedicarboxylic acid, 2,6-dimethyl-4-(3-nitrophenyl)-, ethyl methyl ester
(+/-)-Oxidized Nitrendipine
Bay-m 4786
2,6-Dimethyl-4-(3-nitro-phenyl)-pyridine-3,5-dicarboxylic acid 3-ethyl; ester 5-methyl ester
2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid ethyl methyl ester
Ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
3-ethyl 5-methyl 4-(3-nitrophenyl)-2,6-dimethyl-3,5-pyridinedicarboxylate
3,5-Pyridinedicarboxylic acid,2,6-dimethyl-4-(3-nitrophenyl)-,ethyl methyl ester
ethylmethyl-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
465.4±45.0 °C at 760 mmHg

[ Melting Point ]:
59-61℃

[ Molecular Formula ]:
C₁₈H₁₈N₂O₆

[ Molecular Weight ]:
358.345

[ Flash Point ]:
235.3±28.7 °C

[ Exact Mass ]:
358.116486

[ PSA ]:
111.31000

[ LogP ]:
3.56

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.569

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Pharmacokinetics of nitrendipine in patients with renal failure: comparison to normal subjects.

J. Cardiovasc. Pharmacol. 6 Suppl 7 , S974-6, (1984)

To determine the effect of decreased renal function on the elimination kinetics of the calcium entry blocker nitrendipine and its metabolite, we gave 18 subjects with various levels of renal dysfuncti...