salicyl alcohol

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Names

[ CAS No. ]:
90-01-7

[ Name ]:
salicyl alcohol

[Synonym ]:
α-Hydroxy-o-cresol
2-Hydroxymethylphenol
salicyl alcohol
a,2-Dihydroxytoluene
MFCD00004617
Benzenemethanol, 2-hydroxy-
2-Hydroxybenzenemethanol
EINECS 201-960-5
2-(Hydroxymethyl)phenol
2-Hydroxybenzyl alcohol
α,2-Dihydroxytoluene
O-HYDROXYBENZYL ALCOHOL
2-Hydroxybenzylalcohol
a-Hydroxy-o-cresol
salicylic alcohol
1-(o-Hydroxyphenyl)methanol

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
238.6±7.0 °C at 760 mmHg

[ Melting Point ]:
83-85 °C(lit.)

[ Molecular Formula ]:
C₇H₈O₂

[ Molecular Weight ]:
124.137

[ Flash Point ]:
115.2±12.8 °C

[ Exact Mass ]:
124.052429

[ PSA ]:
40.46000

[ LogP ]:
0.30

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.596

[ Stability ]:
Stable. Incompatible with acids, acid chlorides, acid anhydrides, strong oxidizing agents.

[ Water Solubility ]:
67 g/L (22 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DO6430000

CHEMICAL NAME :: Benzyl alcohol, o-hydroxy-

CAS REGISTRY NUMBER :: 90-01-7

BEILSTEIN REFERENCE NO. :: 1907195

LAST UPDATED :: 199710

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C7-H8-O2

MOLECULAR WEIGHT :: 124.15

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 400 mg/kg

SEX/DURATION :: female 11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 38,209,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80312 No. of Facilities: 141 (estimated) No. of Industries: 3 No. of Occupations: 4 No. of Employees: 3095 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80312 No. of Facilities: 18 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 108 (estimated) No. of Female Employees: 72 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
DO6430000

[ HS Code ]:
29072900

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Salicylaldehyde
2-Methylbenzyl Alcohol
Formaldehyde
Phenol
1-(tert-butyldimethylsilanyloxy)-2-(tert-butyldimethylsilanyloxymethyl)benzene
Methyl salicylate
Aspirin
7-oxabicyclo[4.1.0]hepta-2,4-diene-6-carbaldehyde
6-iodo-2,2-dimethylbenzo[1,3]dioxin-4-one

DownStream

2-ETHOXYCHROMAN
4H-1,3-benzodioxin-2-one
Methyl salicylate
(2-HYDROXYETHYL)TRIETHYLAMMONIUMIODIDE
[2-(2-MORPHOLINOETHOXY)PHENYL]METHANOL
2-Fluorophenol
2-(((2-hydroxybenzyl)amino)methyl)phenol
Phenol,2-[(phenylamino)methyl]-
[2-(hydroxymethyl)phenyl] acetate
salicylaldehyde, oxime

Customs

[ HS Code ]: 2907299090

[ Summary ]:
2907299090 polyphenols; phenol-alcohols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0%

Articles

Cellular apoptosis and cytotoxicity of phenolic compounds: a quantitative structure-activity relationship study.

J. Med. Chem. 48 , 7234-42, (2005)

In this comprehensive study on the caspase-mediated apoptosis-inducing effect of 51 substituted phenols in a murine leukemia cell line (L1210), we determined the concentrations needed to induce caspas...

Functional characterization of two acyltransferases from Populus trichocarpa capable of synthesizing benzyl benzoate and salicyl benzoate, potential intermediates in salicinoid phenolic glycoside biosynthesis.

Phytochemistry 113 , 149-59, (2015)

Salicinoids are phenolic glycosides (PGs) characteristic of the Salicaceae and are known defenses against insect herbivory. Common examples are salicin, salicortin, tremuloidin, and tremulacin, which ...

Salicyl alcohol oxidase of the chemical defense secretion of two chrysomelid leaf beetles. Molecular and functional characterization of two new members of the glucose-methanol-choline oxidoreductase gene family.

J. Biol. Chem. 283(28) , 19219-28, (2008)

Salicyl alcohol oxidase is an extracellular enzyme that occurs in glandular reservoirs of chrysomelid leaf beetle larvae and catalyzes the formation of salicylaldehyde, a volatile deterrent used by th...