Diethylcarbamazine

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Names

[ CAS No. ]:
90-89-1

[ Name ]:
Diethylcarbamazine

[Synonym ]:
patonin
4-methyl-piperazine-1-carboxylic acid diethylamide
Caracide
84L
Caricide
Notezine
rp3799
Cypip
diethycarbamazine
Banocide
4-Methyl-piperazin-1-carbonsaeure-diaethylamid
Diethylcarbamazine
Ethodryl

Chemical & Physical Properties

[ Density]:
1.013g/cm3

[ Boiling Point ]:
139ºC

[ Melting Point ]:
137 - 140ºC

[ Molecular Formula ]:
C10H21N3O

[ Molecular Weight ]:
199.29300

[ Flash Point ]:
98ºC

[ Exact Mass ]:
199.16800

[ PSA ]:
26.79000

[ LogP ]:
0.57140

[ Index of Refraction ]:
1.492

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TL1200000
CHEMICAL NAME :
1-Piperazinecarboxamide, N,N-diethyl-4-methyl-
CAS REGISTRY NUMBER :
90-89-1
BEILSTEIN REFERENCE NO. :
0143029
LAST UPDATED :
199701
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C10-H21-N3-O
MOLECULAR WEIGHT :
199.34

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
7300 mg/kg/1Y-I
TOXIC EFFECTS :
Skin and Appendages - dermatitis, allergic (after systemic exposure)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
240 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
630 mg/kg
SEX/DURATION :
female 7-11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
TYPE OF TEST :
Micronucleus test

MUTATION DATA

TEST SYSTEM :
Rodent - mouse
DOSE/DURATION :
40 mg/kg
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 44,7,1988 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2728 No. of Facilities: 316 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 3161 (estimated) No. of Female Employees: 1581 (estimated)

Synthetic Route

Click to get detail synthetic route

Related Compounds

  • Diethylcarbamazine N-oxide
  • Diethylcarbamazine Citrate
  • Diethylcarbamazine pamoate
  • Diethylcarbamazine hydridochloride
  • 5-amino-1-(4-chlorophenyl)-N-(1-phenylethyl)-1H-1,2,3-triazole-4-carboxamide
  • [4-(1H-benzimidazol-2-yl)piperidin-1-yl][4-(2-methylpropoxy)phenyl]methanone
  • 2-[(6-Chloro-2-fluorophenyl)methylene]-6-hydroxy-7-[(4-methylpiperidyl)methyl] benzo[b]furan-3-one
  • 5-chloro-2-[(4-chlorobenzyl)sulfanyl]-N-(4-chlorophenyl)pyrimidine-4-carboxamide
  • 3-[2-(4-fluorophenyl)-1H-indol-3-yl]-N-(5-methyl-1,2-oxazol-3-yl)propanamide
  • Ethyl 6-(2,4-dimethoxyphenyl)-2-[4-(2-methoxyphenyl)piperazino]-4-oxo-1,4,5,6-tetrahydro-5-pyrimidinecarboxylate
  • 4-Hydroxypyrrolidin-3-one
  • Boc-N-Me-Asp(OBzl)-OH
  • N-(4-{[1-(4-fluorophenyl)-1H-tetrazol-5-yl]methoxy}phenyl)acetamide
  • 2H-Pyran, 4-chloro-3-ethyltetrahydro-, trans-
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