Diethylcarbamazine

Modify Date: 2025-08-26 22:06:22

Diethylcarbamazine structure	Common Name	Diethylcarbamazine
	CAS Number	90-89-1	Molecular Weight	199.29300
	Density	1.013g/cm3	Boiling Point	139ºC
	Molecular Formula	C₁₀H₂₁N₃O	Melting Point	137 - 140ºC
	MSDS	N/A	Flash Point	98ºC

Use of Diethylcarbamazine

Diethylcarbamazine is a microfilaricidal drug used originally in onchocerciasis and lymphatic filiariasis study[1].

Name	n,n-diethyl-4-methyl-1-piperazinecarboxamide
Synonym	More Synonyms

Description	Diethylcarbamazine is a microfilaricidal drug used originally in onchocerciasis and lymphatic filiariasis study[1].
Related Catalog	Research Areas >> Inflammation/Immunology
References	[1]. M García-Hernández, et al. Immunomodulatory effect of diethylcarbamazine in mice infected with Nocardia brasiliensis. Int Immunopharmacol. 2014 Nov;23(1):113-20.

Density	1.013g/cm3
Boiling Point	139ºC
Melting Point	137 - 140ºC
Molecular Formula	C₁₀H₂₁N₃O
Molecular Weight	199.29300
Flash Point	98ºC
Exact Mass	199.16800
PSA	26.79000
LogP	0.57140
Index of Refraction	1.492

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TL1200000

CHEMICAL NAME :: 1-Piperazinecarboxamide, N,N-diethyl-4-methyl-

CAS REGISTRY NUMBER :: 90-89-1

BEILSTEIN REFERENCE NO. :: 0143029

LAST UPDATED :: 199701

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C10-H21-N3-O

MOLECULAR WEIGHT :: 199.34

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 7300 mg/kg/1Y-I

TOXIC EFFECTS :: Skin and Appendages - dermatitis, allergic (after systemic exposure)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 240 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 630 mg/kg

SEX/DURATION :: female 7-11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :: Micronucleus test

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 40 mg/kg

REFERENCE :: TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 44,7,1988 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2728 No. of Facilities: 316 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 3161 (estimated) No. of Female Employees: 1581 (estimated)

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Diethylcarbamazine

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