Streptokinase

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Names

[ CAS No. ]:
9002-01-1

[ Name ]:
Streptokinase

[Synonym ]:
L-Proline,4-cyclohexyl-,(4S)
MFCD00082037
Streptokinase
4-Cyclohexylproline
4-cyclohexyl-2-pyrrolidinecarboxylic acid
Proline, 4-cyclohexyl-

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
343.9±35.0 °C at 760 mmHg

[ Molecular Formula ]:
C11H19NO2

[ Molecular Weight ]:
197.274

[ Flash Point ]:
161.8±25.9 °C

[ Exact Mass ]:
197.141586

[ PSA ]:
49.33000

[ LogP ]:
1.99

[ Appearance of Characters ]:
lyophilized powder

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.517

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
OB8880000
CHEMICAL NAME :
Kinase (enzyme-activating), strepto-
CAS REGISTRY NUMBER :
9002-01-1
LAST UPDATED :
199512

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Human
DOSE/DURATION :
600 iu/kg
TOXIC EFFECTS :
Immunological Including Allergic - uncharacterized
REFERENCE :
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 252,1314,1984
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
562500 iu/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 252,1314,1984
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 43,671,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FOHEAW Folia Haematologica (Leipzig). (Buchexport, Postfach 160, Leipzig DDR-7010, Ger. Dem. Rep.) V.32- 1926- Volume(issue)/page/year: 103,445,1976
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FOHEAW Folia Haematologica (Leipzig). (Buchexport, Postfach 160, Leipzig DDR-7010, Ger. Dem. Rep.) V.32- 1926- Volume(issue)/page/year: 103,445,1976
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 43,671,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4087 No. of Facilities: 41 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 9366 (estimated) No. of Female Employees: 8266 (estimated)

Safety Information

[ Hazard Codes ]:
C,Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
22-24/25-36-26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
OB8880000

Preparation

Articles

Staphylokinase, a fibrin-specific plasminogen activator with therapeutic potential?

Blood 84 , 680-6, (1994)

Primary coronary intervention versus thrombolytic therapy in myocardial infarction patients in the Middle East Al-Zakwani, I., et al.

J. Am. Med. Assoc. 34(3) , 445-51, (2012)

Effects of plasminogen and streptokinase on the vital functions of nervous tissue cells in culture Nikandrov, V., et al.

Biomed. Khim. 54 , 192-200, (2012)


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Related Compounds

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