Detomidine hydrochloride

Names

[ Name ]:
Detomidine hydrochloride

[Synonym ]:
1H-Imidazole, 5-[(2,3-dimethylphenyl)methyl]-, hydrochloride (1:1)
5-[(2,3-dimethylphenyl)methyl]-1H-imidazole,hydrochloride
4-(2,3-Dimethylbenzyl)-1H-imidazole hydrochloride (1:1)

Chemical & Physical Properties

[ Boiling Point ]:
386.5ºC at 760mmHg

[ Melting Point ]:
160ºC

[ Molecular Formula ]:
C₁₂H₁₅ClN₂

[ Molecular Weight ]:
222.714

[ Flash Point ]:
200.6ºC

[ Exact Mass ]:
222.092377

[ PSA ]:
28.68000

[ LogP ]:
3.41930

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NI5160000

CHEMICAL NAME :: 1H-Imidazole, 4-((2,3-dimethylphenyl)methyl)-, monohydrochloride

CAS REGISTRY NUMBER :: 90038-01-0

LAST UPDATED :: 199009

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C12-H14-N2.Cl-H

MOLECULAR WEIGHT :: 222.74

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 35 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4443466

Safety Information

[ Hazard Codes ]:
Xi

[ RIDADR ]:
UN 2811 6.1 / PGIII

[ RTECS ]:
NI5160000

[ HS Code ]:
2933290090

Customs

[ HS Code ]: 2933290090

[ Summary ]:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Atipamezole antagonism of an ACTH stimulation test in ponies sedated with detomidine.

J. Vet. Pharmacol. Ther. 34(5) , 508-11, (2011)

Influence of detomidine and xylazine on spleen dimensions and on splenic response to epinephrine infusion in healthy adult horses.

Vet. Anaesth. Analg. 40(4) , 375-81, (2013)

To compare the changes in splenic length and thickness and in packed cell volume (PCV) following detomidine or xylazine administration and subsequent epinephrine infusion.Spleen relaxation occurs foll...

Comparison of the mechanical hypoalgesic effects of five α2-adrenoceptor agonists in donkeys.

Vet. Rec. 173(12) , 294, (2013)

Pharmacological pain management is necessary under many clinical situations, but in donkeys little information on analgesic drugs is available. This controlled, randomised, crossover, Latin-square, op...

3-Hydroxy Detomidine Hydrochloride
Detomidine hydrochloride monohydrate
3-Hydroxy DetoMidine-15N2,d2 Hydrochloride
Tyrocidine, hydrochloride
Triprolidine hydrochloride
Minoxidil hydrochloride
[4-(3-bromophenyl)-1,1-dioxido-4H-1,4-benzothiazin-2-yl](3,4-dimethoxyphenyl)methanone
[4-(4-bromophenyl)-1,1-dioxido-4H-1,4-benzothiazin-2-yl](3,4-dimethoxyphenyl)methanone
(3,4-dimethoxyphenyl)[6-fluoro-4-(3-methoxyphenyl)-1,1-dioxido-4H-1,4-benzothiazin-2-yl]methanone
(3,4-dimethoxyphenyl)[6-fluoro-4-(4-fluorophenyl)-1,1-dioxido-4H-1,4-benzothiazin-2-yl]methanone
N-(3,4-dimethylphenyl)-4-(3-fluorophenyl)-3-[methyl(phenyl)sulfamoyl]thiophene-2-carboxamide
3-butyl-2-(((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methyl)thio)quinazolin-4(3H)-one
2-(((5-methyl-2-(o-tolyl)oxazol-4-yl)methyl)thio)-3-phenylquinazolin-4(3H)-one
2-(((2-(4-methoxyphenyl)-5-methyloxazol-4-yl)methyl)thio)-3-phenylquinazolin-4(3H)-one
2-(((2-(4-ethoxyphenyl)-5-methyloxazol-4-yl)methyl)thio)-3-(4-methoxyphenyl)quinazolin-4(3H)-one
3-(3-methoxyphenyl)-2-(((2-(2-methoxyphenyl)-5-methyloxazol-4-yl)methyl)thio)quinazolin-4(3H)-one

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