Detomidine hydrochloride
Modify Date: 2024-01-07 08:11:08
Detomidine hydrochloride structure
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Common Name | Detomidine hydrochloride | ||
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| CAS Number | 90038-01-0 | Molecular Weight | 222.714 | |
| Density | N/A | Boiling Point | 386.5ºC at 760mmHg | |
| Molecular Formula | C12H15ClN2 | Melting Point | 160ºC | |
| MSDS | N/A | Flash Point | 200.6ºC | |
Use of Detomidine hydrochlorideDetomidine hydrochloride produce dose-dependent sedative and analgesic effects, is a nonnarcotic, synthetic α2-adrenergic agonistTarget: α2-adrenergic agonistDetomidine is an imidazole derivative and α2-adrenergic agonist, used as a large animal sedative, primarily used in horses. It is usually available as the salt detomidine hydrochloride. It is a prescription medication available to veterinarians sold under the trade name Dormosedan. Currently, detomidine is only licenced for use in horses.Detomidine is a sedative with analgesic properties. α2-adrenergic agonists produce dose-dependent sedative and analgesic effects, mediatated by activation of α2 catecholamine receptors, thus inducing a negative feedback response, reducing production of excitatory neurotransmitters. Due to inhibition of the sympathetic nervous system, detomidine also has cardiac and respiratory effects and an antidiuretic action. |
| Name | Detomidine Hydrochloride |
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| Synonym | More Synonyms |
| Description | Detomidine hydrochloride produce dose-dependent sedative and analgesic effects, is a nonnarcotic, synthetic α2-adrenergic agonistTarget: α2-adrenergic agonistDetomidine is an imidazole derivative and α2-adrenergic agonist, used as a large animal sedative, primarily used in horses. It is usually available as the salt detomidine hydrochloride. It is a prescription medication available to veterinarians sold under the trade name Dormosedan. Currently, detomidine is only licenced for use in horses.Detomidine is a sedative with analgesic properties. α2-adrenergic agonists produce dose-dependent sedative and analgesic effects, mediatated by activation of α2 catecholamine receptors, thus inducing a negative feedback response, reducing production of excitatory neurotransmitters. Due to inhibition of the sympathetic nervous system, detomidine also has cardiac and respiratory effects and an antidiuretic action. |
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| Related Catalog | |
| References |
| Boiling Point | 386.5ºC at 760mmHg |
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| Melting Point | 160ºC |
| Molecular Formula | C12H15ClN2 |
| Molecular Weight | 222.714 |
| Flash Point | 200.6ºC |
| Exact Mass | 222.092377 |
| PSA | 28.68000 |
| LogP | 3.41930 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| Hazard Codes | Xi |
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| RIDADR | UN 2811 6.1 / PGIII |
| RTECS | NI5160000 |
| HS Code | 2933290090 |
| HS Code | 2933290090 |
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| Summary | 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Atipamezole antagonism of an ACTH stimulation test in ponies sedated with detomidine.
J. Vet. Pharmacol. Ther. 34(5) , 508-11, (2011)
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Influence of detomidine and xylazine on spleen dimensions and on splenic response to epinephrine infusion in healthy adult horses.
Vet. Anaesth. Analg. 40(4) , 375-81, (2013) To compare the changes in splenic length and thickness and in packed cell volume (PCV) following detomidine or xylazine administration and subsequent epinephrine infusion.Spleen relaxation occurs foll... |
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Comparison of the mechanical hypoalgesic effects of five α2-adrenoceptor agonists in donkeys.
Vet. Rec. 173(12) , 294, (2013) Pharmacological pain management is necessary under many clinical situations, but in donkeys little information on analgesic drugs is available. This controlled, randomised, crossover, Latin-square, op... |
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