rubitecan
Suppliers
Names
[ CAS No. ]:
91421-42-0
[ Name ]:
rubitecan
[Synonym ]:
rubitecan
MFCD06656294
1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-10-nitro-, (4S)-
PYRIDOXINE 3,4-DIPALMITATE
9-nitro-20(s)-camptothecin
1H-PYRANO[3',4':6,7]INDOLIZINO[1,2-B]QUINOLINE-3,14(4H,12H)-DIONE,4-ETHYL-4-HYDROXY-10-NITRO-, (4S)-
(4S)-4-Ethyl-4-hydroxy-10-nitro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
Orathecin
Chemical & Physical Properties
[ Density]:
1.6±0.1 g/cm3
[ Boiling Point ]:
816.3±65.0 °C at 760 mmHg
[ Melting Point ]:
182-186ºC
[ Molecular Formula ]:
C20H15N3O6
[ Molecular Weight ]:
393.350
[ Flash Point ]:
447.5±34.3 °C
[ Exact Mass ]:
393.096100
[ PSA ]:
127.24000
[ LogP ]:
1.38
[ Vapour Pressure ]:
0.0±3.1 mmHg at 25°C
[ Index of Refraction ]:
1.762
[ Storage condition ]:
Room temp
MSDS
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ RIDADR ]:
NONH for all modes of transport
[ RTECS ]:
UQ0493300
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
Int. J. Pharm. 340(1-2) , 29-33, (2007)
Pharmacokinetics and lactone/carboxylate equilibrium of 9-Nitrocamptothecin (9-NC) were compared after intravenous (i.v.) and intramuscular (i.m.) injection at a dose of 1.5mg/kg 9-NC solution. The co...
Drug Dev. Ind. Pharm. 32(6) , 719-26, (2006)
9-Nitrocamptothecin (9-NC), a newly developed camptothecin derivative, had poor solubility in any pharmaceutically acceptable solvents. One way of improving the solubility is to formulate the drug int...
Mol. Cancer Ther. 5(8) , 2130-7, (2006)
Resistance to topoisomerase (topo) I inhibitors has been related to down-regulation of nuclear target enzyme, whereas sensitization to topo II inhibitors may result from induction of topo II by topo I...