rubitecan

Modify Date: 2025-08-25 10:31:46

rubitecan structure	Common Name	rubitecan
	CAS Number	91421-42-0	Molecular Weight	393.350
	Density	1.6±0.1 g/cm3	Boiling Point	816.3±65.0 °C at 760 mmHg
	Molecular Formula	C₂₀H₁₅N₃O₆	Melting Point	182-186ºC
	MSDS	USA	Flash Point	447.5±34.3 °C

Use of rubitecan

Rubitecan (RFS 2000), a camptothecin derivative, is an orally active topoisomerase I inhibitor with broad antitumor activity, and induces protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells[1][2][3].

Name	9-Nitrocamptothecin
Synonym	More Synonyms

Description	Rubitecan (RFS 2000), a camptothecin derivative, is an orally active topoisomerase I inhibitor with broad antitumor activity, and induces protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells[1][2][3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase
Target	Topoisomerase I[1]
In Vitro	Rubitecan (RFS 2000) inhibits U-CH1, U-CH2, and CCL4 cells with IC50s 0.32, 0.83, and 7.7 µM, respectively[4].
References	[1]. Burris HA 3rd, et al. Phase II trial of oral rubitecan in previously treated pancreatic cancer patients. Oncologist. 2005 Mar;10(3):183-90. [2]. Rubitecan: 9-NC, 9-Nitro-20(S)-camptothecin, 9-nitro-camptothecin, 9-nitrocamptothecin, RFS 2000, RFS2000. Drugs R D. 2004;5(5):305-11. [3]. Rubitecan [4]. Xia M, et al. Identification of repurposed small molecule drugs for chordoma therapy. Cancer Biol Ther. 2013 Jul;14(7):638-47.

Density	1.6±0.1 g/cm3
Boiling Point	816.3±65.0 °C at 760 mmHg
Melting Point	182-186ºC
Molecular Formula	C₂₀H₁₅N₃O₆
Molecular Weight	393.350
Flash Point	447.5±34.3 °C
Exact Mass	393.096100
PSA	127.24000
LogP	1.38
Vapour Pressure	0.0±3.1 mmHg at 25°C
Index of Refraction	1.762
Storage condition	Room temp

rubitecan MSDS(Chinese)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
RTECS	UQ0493300

Precursor 6
CAS#:172917-96-3 (S)-4-ethyl-4-h... CAS#:172917-94-1 (S)-4-ethyl-4-h... CAS#:164159-91-5 (S)-4-ethyl-4-h... CAS#:7689-03-4 Campathecin
CAS#:19685-09-7 (S)-10-Hydroxyc... CAS#:104267-73-4 9-Nitro-10-hydr...
DownStream 4
CAS#:91421-43-1 9-Aminocamptothecin CAS#:7689-03-4 Campathecin CAS#:67656-30-8 9-Hydroxycampto... CAS#:39026-92-1 9-Methoxycampto...

Effect of injection routes on pharmacokinetics and lactone/carboxylate equilibrium of 9-Nitrocamptothecin in rats.

Int. J. Pharm. 340(1-2) , 29-33, (2007)

Pharmacokinetics and lactone/carboxylate equilibrium of 9-Nitrocamptothecin (9-NC) were compared after intravenous (i.v.) and intramuscular (i.m.) injection at a dose of 1.5mg/kg 9-NC solution. The co...

Effect of phospholipid composition on characterization of liposomes containing 9-nitrocamptothecin.

Drug Dev. Ind. Pharm. 32(6) , 719-26, (2006)

9-Nitrocamptothecin (9-NC), a newly developed camptothecin derivative, had poor solubility in any pharmaceutically acceptable solvents. One way of improving the solubility is to formulate the drug int...

Sequential oral 9-nitrocamptothecin and etoposide: a pharmacodynamic- and pharmacokinetic-based phase I trial.

Mol. Cancer Ther. 5(8) , 2130-7, (2006)

Resistance to topoisomerase (topo) I inhibitors has been related to down-regulation of nuclear target enzyme, whereas sensitization to topo II inhibitors may result from induction of topo II by topo I...

rubitecan

MFCD06656294

1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-10-nitro-, (4S)-

PYRIDOXINE 3,4-DIPALMITATE

9-nitro-20(s)-camptothecin

1H-PYRANO[3',4':6,7]INDOLIZINO[1,2-B]QUINOLINE-3,14(4H,12H)-DIONE,4-ETHYL-4-HYDROXY-10-NITRO-, (4S)-

(4S)-4-Ethyl-4-hydroxy-10-nitro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

Orathecin

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: rubitecan
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: rubitecan
Price: ￥1928.0/100mg
Purity: 98.0%
Delivery: Inquiry
Contact: Liu jia
Email: 2130147988@qq.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: RFS 2000
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

DC Chemicals Limited
China
Product Name: RFS 2000
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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Price: ￥936/50mg

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rubitecan

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