Methotrexate

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Names

[ CAS No. ]:
91431-42-4

[ Name ]:
Methotrexate

[Synonym ]:
6-chloro-1,4-diacetoxy-2,3-dimethoxynaphthalene
LONAPALENE
Lonapaleno
Lonapalenum
6-chloro-2,3-dimethoxy-1,4-naphthalenediol
1,4-diacetoxy-6-chloro-2,3-dimethoxynaphthalene
6-chloro-1,4-diacetyloxy-2,3-dimethoxynaphthalene
Methotrexate
RS4317

Chemical & Physical Properties

[ Density]:
1.309g/cm3

[ Boiling Point ]:
424.9ºC at 760mmHg

[ Molecular Formula ]:
C16H15ClO6

[ Molecular Weight ]:
338.74000

[ Flash Point ]:
159.3ºC

[ Exact Mass ]:
338.05600

[ PSA ]:
71.06000

[ LogP ]:
3.36100

[ Index of Refraction ]:
1.571

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-Bromochlorobenzene
  • 6-chloronaphthalene-1,4-dione
  • 1,4-Benzoquinone
  • 2,3-DIMETHOXY-1,4-BENZOQUINONE
  • acetic acid,7-chloro-2,3,5-trimethoxy-5,8-dihydronaphthalene-1,4-diol

DownStream

Related Compounds

  • Methotrexate
  • methotrexate
  • methotrexate
  • d-methotrexate
  • D-Methotrexate
  • Methotrexate-d3
  • N,N-dimethyl-4-{4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}piperidine-1-sulfonamide
  • 4-[(4-{4-[5-(Trifluoromethyl)pyridin-2-yl]piperazin-1-yl}piperidin-1-yl)sulfonyl]morpholine
  • 1-{1-[4-(Pyridin-3-yloxy)benzenesulfonyl]piperidin-4-yl}-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine
  • 1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-4-{1-[(1,2-dimethyl-1H-imidazol-4-yl)sulfonyl]piperidin-4-yl}piperazine
  • 2-({3-[2-(4-chlorophenyl)ethyl]-4-oxo-3H,4H-thieno[3,2-d]pyrimidin-2-yl}sulfanyl)-N-(2-ethoxyphenyl)acetamide
  • N-(4-carbamoylthiophen-3-yl)-4-methyl-1,2,3-thiadiazole-5-carboxamide
  • N-(4-methylphenyl)-3-(methylsulfanyl)pyrrolidine-1-carboxamide
  • tert-Butyl1-aminocyclopentanecarboxylatehydrochloride
  • N-(2H-1,3-benzodioxol-5-yl)-3-(methylsulfanyl)pyrrolidine-1-carboxamide
  • 1-[(3-Chlorophenyl)methanesulfonyl]-3-(methylsulfanyl)pyrrolidine
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