Methotrexate

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Names

[ CAS No. ]:
91431-42-4

[ Name ]:
Methotrexate

[Synonym ]:
6-chloro-1,4-diacetoxy-2,3-dimethoxynaphthalene
LONAPALENE
Lonapaleno
Lonapalenum
6-chloro-2,3-dimethoxy-1,4-naphthalenediol
1,4-diacetoxy-6-chloro-2,3-dimethoxynaphthalene
6-chloro-1,4-diacetyloxy-2,3-dimethoxynaphthalene
Methotrexate
RS4317

Chemical & Physical Properties

[ Density]:
1.309g/cm3

[ Boiling Point ]:
424.9ºC at 760mmHg

[ Molecular Formula ]:
C16H15ClO6

[ Molecular Weight ]:
338.74000

[ Flash Point ]:
159.3ºC

[ Exact Mass ]:
338.05600

[ PSA ]:
71.06000

[ LogP ]:
3.36100

[ Index of Refraction ]:
1.571

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-Bromochlorobenzene
  • 6-chloronaphthalene-1,4-dione
  • 1,4-Benzoquinone
  • 2,3-DIMETHOXY-1,4-BENZOQUINONE
  • acetic acid,7-chloro-2,3,5-trimethoxy-5,8-dihydronaphthalene-1,4-diol

DownStream

Related Compounds

  • Methotrexate
  • methotrexate
  • methotrexate
  • d-methotrexate
  • D-Methotrexate
  • Methotrexate-d3
  • 5-ethyl-N-(2-(furan-2-yl)-2-hydroxy-2-(thiophen-2-yl)ethyl)thiophene-2-sulfonamide
  • 2,6-difluoro-N-(2-(furan-2-yl)-2-hydroxy-2-(thiophen-2-yl)ethyl)benzenesulfonamide
  • N-(2-(furan-2-yl)-2-hydroxy-2-(thiophen-2-yl)ethyl)-4-methoxy-2-methylbenzenesulfonamide
  • 4-Bromo-1-propyl-1H-pyrazole-5-carbonitrile
  • 5-fluoro-N-(2-(furan-2-yl)-2-hydroxy-2-(thiophen-2-yl)ethyl)-2-methoxybenzenesulfonamide
  • 3-chloro-N-(2-(furan-2-yl)-2-hydroxy-2-(thiophen-2-yl)ethyl)-4-methoxybenzenesulfonamide
  • N-(2-(furan-2-yl)-2-hydroxy-2-(thiophen-2-yl)ethyl)-3-(trifluoromethyl)benzenesulfonamide
  • N-(2-(furan-2-yl)-2-hydroxy-2-(thiophen-2-yl)ethyl)-4-(trifluoromethoxy)benzenesulfonamide
  • 1-(3,5-difluorophenyl)-N-(2-(furan-2-yl)-2-hydroxy-2-(thiophen-2-yl)ethyl)methanesulfonamide
  • N-(2-(furan-2-yl)-2-hydroxy-2-(thiophen-2-yl)ethyl)-1-isopropyl-1H-imidazole-4-sulfonamide