Methotrexate
Methotrexate structure
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Common Name | Methotrexate | ||
|---|---|---|---|---|
| CAS Number | 91431-42-4 | Molecular Weight | 338.74000 | |
| Density | 1.309g/cm3 | Boiling Point | 424.9ºC at 760mmHg | |
| Molecular Formula | C16H15ClO6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 159.3ºC | |
Use of MethotrexateRS4317 is a topically effective 5-lipoxygenase (5-LO) inhibitor. |
| Name | (4-acetyloxy-6-chloro-2,3-dimethoxynaphthalen-1-yl) acetate |
|---|---|
| Synonym | More Synonyms |
| Description | RS4317 is a topically effective 5-lipoxygenase (5-LO) inhibitor. |
|---|---|
| Related Catalog | |
| Target |
5-lipoxygenase[1] |
| In Vitro | RS4317 (Lonapalene) may be useful in the treatment of psoriasis, and that leukotriene B4 is a relevant mediator of the pathology of this disease[1]. |
| References |
| Density | 1.309g/cm3 |
|---|---|
| Boiling Point | 424.9ºC at 760mmHg |
| Molecular Formula | C16H15ClO6 |
| Molecular Weight | 338.74000 |
| Flash Point | 159.3ºC |
| Exact Mass | 338.05600 |
| PSA | 71.06000 |
| LogP | 3.36100 |
| Index of Refraction | 1.571 |
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Methotrexate CAS#:91431-42-4 |
| Literature: Moore, Harold W.; Perri, Steven T. Journal of Organic Chemistry, 1988 , vol. 53, # 5 p. 996 - 1003 |
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Methotrexate CAS#:91431-42-4 |
| Literature: Jones, Gordon H.; Venuti, Michael C.; Young, John M.; Murthy, D.V. Krishna; Loe, Brad E.; et al. Journal of Medicinal Chemistry, 1986 , vol. 29, # 8 p. 1504 - 1511 |
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Methotrexate CAS#:91431-42-4 |
| Literature: Jones, Gordon H.; Venuti, Michael C.; Young, John M.; Murthy, D.V. Krishna; Loe, Brad E.; et al. Journal of Medicinal Chemistry, 1986 , vol. 29, # 8 p. 1504 - 1511 |
|
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Methotrexate CAS#:91431-42-4 |
| Literature: Flynn; Nies Tetrahedron Letters, 1986 , vol. 27, # 42 p. 5075 - 5078 |
|
~%
Methotrexate CAS#:91431-42-4 |
| Literature: Flynn; Nies Tetrahedron Letters, 1986 , vol. 27, # 42 p. 5075 - 5078 |
| 6-chloro-1,4-diacetoxy-2,3-dimethoxynaphthalene |
| LONAPALENE |
| Lonapaleno |
| Lonapalenum |
| 6-chloro-2,3-dimethoxy-1,4-naphthalenediol |
| 1,4-diacetoxy-6-chloro-2,3-dimethoxynaphthalene |
| 6-chloro-1,4-diacetyloxy-2,3-dimethoxynaphthalene |
| Methotrexate |
| RS4317 |