demeton-S-methyl
Suppliers
Names
[ CAS No. ]:
919-86-8
[ Name ]:
demeton-S-methyl
[Synonym ]:
Methyl isosystox
S-[2-(ethylsulfanyl)ethyl] O,O-dimethyl phosphorothioate
Metaisosystox
DEMETON-S-METHYL
S-2-ethylthioethyl O,O-dimethyl phosphorothioate
MFCD00055464
Thiometon oxon
Demetox
Metasystox J
O,O-dimethyl S-2-ethylthioethyl phosphorothioate
methylmercaptophos thiol
Metasystox 55
1-dimethoxyphosphorylsulfanyl-2-ethylsulfanylethane
EINECS 213-052-6
Metaisoseptox
S-[2-(ethylthio)ethyl] O,O-dimethyl phosphorothioate
Duratox
Methyldemetone
Chemical & Physical Properties
[ Density]:
1.197g/cm3
[ Boiling Point ]:
287.4ºC at 760 mmHg
[ Melting Point ]:
<25℃
[ Molecular Formula ]:
C6H15O3PS2
[ Molecular Weight ]:
230.28500
[ Flash Point ]:
2ºC
[ Exact Mass ]:
230.02000
[ PSA ]:
95.94000
[ LogP ]:
2.87360
[ Index of Refraction ]:
1.496
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TG1750000
- CHEMICAL NAME :
- Phosphorothioic acid, S-(2-(ethylthio)ethyl) O,O-dimethyl ester
- CAS REGISTRY NUMBER :
- 919-86-8
- BEILSTEIN REFERENCE NO. :
- 1707311
- LAST UPDATED :
- 199703
- DATA ITEMS CITED :
- 14
- MOLECULAR FORMULA :
- C6-H15-O3-P-S2
- MOLECULAR WEIGHT :
- 230.30
- WISWESSER LINE NOTATION :
- 2S2SPO&O1&O1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 30 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 500 mg/m3/4H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 85 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 7500 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 65 mg/kg
- TOXIC EFFECTS :
- Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other esterases
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 110 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 12500 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Mammal - species unspecified
- DOSE/DURATION :
- 40 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA
- TEST SYSTEM :
- Insect - Drosophila melanogaster
- DOSE/DURATION :
- 80 ppm
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 28,405,1975 *** REVIEWS *** TOXICOLOGY REVIEW DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970. Volume(issue)/page/year: 80,485,1973 TOXICOLOGY REVIEW RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year: 63,1,1976
Safety Information
[ Symbol ]:
GHS06, GHS09
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H301 + H311-H411
[ Precautionary Statements ]:
P273-P280-P301 + P310 + P330-P302 + P352 + P312-P391-P501
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
T,N,Xn,F
[ Risk Phrases ]:
24/25-51/53-36-20/21/22-11
[ Safety Phrases ]:
S26;S36/S37
[ RIDADR ]:
UN 3018
[ RTECS ]:
TG1750000
[ Packaging Group ]:
II
[ Hazard Class ]:
6.1(a)
Synthetic Route
Articles
Biochem. Biophys. Res. Commun. 279(2) , 516-9, (2000)
Organophosphorus hydrolase (OPH) is capable of hydrolyzing a wide variety of organophosphorus pesticides and chemical warfare agents. However, the hydrolytic activity of OPH against the warfare agent ...
Eisei Shikenjo Hokoku. (114) , 95-8, (1996)
Genes coding for cytochrome P450 are regulated by endogenous hormones such as the growth hormone, corticosteroids, thyroid, and sex hormones. Secretion of these hormones is regulated by the respective...
EEG EMG Z. Elektroenzephalogr. Elektromyogr. Verwandte Geb. 20(1) , 28-33, (1989)
Repetitive stimulation of the median nerve elicited a so far unknown course of the muscle action potentials in four patients with organophosphate intoxications. The amplitude of the initial muscle act...