2-(Triflouomethyl) phenothiazine

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Names

[ CAS No. ]:
92-30-8

[ Name ]:
2-(Triflouomethyl) phenothiazine

[Synonym ]:
Phenothiazine, 2- (trifluoromethyl)-
EINECS 202-145-7
2-(Trifluoromethyl)-10H-phenothiazine
10H-Phenothiazine, 2-(trifluoromethyl)-
2-(Triflouomethyl) phenothiazine
MFCD00005018
10H-Phenothiazine, 2- (trifluoromethyl)-

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
361.1±42.0 °C at 760 mmHg

[ Melting Point ]:
188-190 °C(lit.)

[ Molecular Formula ]:
C13H8F3NS

[ Molecular Weight ]:
267.270

[ Flash Point ]:
172.2±27.9 °C

[ Exact Mass ]:
267.032959

[ PSA ]:
37.33000

[ LogP ]:
5.50

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.588

[ Storage condition ]:
2-8°C

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SP5620000
CHEMICAL NAME :
Phenothiazine, 2-(trifluoromethyl)-
CAS REGISTRY NUMBER :
92-30-8
BEILSTEIN REFERENCE NO. :
0226580
LAST UPDATED :
199712
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C13-H8-F3-N-S
MOLECULAR WEIGHT :
267.28
WISWESSER LINE NOTATION :
T C666 BM ISJ EXFFF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
520 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - rigidity (including catalepsy) Behavioral - muscle contraction or spasticity
REFERENCE :
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 12,110,1971
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
32 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#07426

Safety Information

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
S36

[ WGK Germany ]:
3

[ RTECS ]:
SP5620000

[ HS Code ]:
2934300000

Synthetic Route

Precursor & DownStream

Precursor

  • 1-Bromo-2-iodobenzene
  • 3-Amino-4-mercaptobenzotrifluoride
  • 2-Bromochlorobenzene
  • Cyclohexanone
  • Benzenamine,N-phenyl-3-(trifluoromethyl)-
  • 3-[10-(2-trifluoromethylphenothiazinyl)]propionyl chloride
  • Flufenamic Acid

DownStream

  • Ethanone,2-chloro-1-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]-
  • 1-Piperazineethanol,4-[3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl]-, 1-acetate
  • 10H-Phenothiazine,10-(2-chloroethyl)-2-(trifluoromethyl)-
  • Fluacizine
  • N-Desmethyl Trifluoperazine Dihydrochloride
  • 3-CHLORO-1-(2-TRIFLUOROMETHYL-PHENOTHIAZIN-10-YL)-PROPAN-1-ONE
  • Fluphenazine
  • Trifluoperazine
  • Ftormetazine
  • 3-morpholin-4-yl-1-[2-(trifluoromethyl)phenothiazin-10-yl]propan-1-one

Customs

[ HS Code ]: 2934300000

[ Summary ]:
2934300000. other compounds containing in the structure a phenothiazine ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%


Related Compounds

  • 2-[phenothiazine-10-carbonyl-[2-(phenylcarbamoyloxy)ethyl]amino]ethyl N-phenylcarbamate
  • (E)-3-(4-difluoromethoxyphenyl)-2-(phenothiazine-10-carbonyl)acrylonitrile
  • 2-acetyl-phenothiazine-10-carboxylic acid 3-dimethylamino-propyl ester
  • 2-butyryl-phenothiazine-10-carboxylic acid 3-dimethylamino-propyl ester
  • 2-methylsulfanyl-phenothiazine-10-carboxylic acid hydrazide
  • 2-(Ethylthio)phenothiazine
  • 5-(1-Isocyanatoethyl)-2-(pyrrolidin-1-yl)pyridine
  • (2R)-2-[2-methoxy-3-(trifluoromethyl)phenyl]oxirane
  • 3-methyl-1-{[methyl({8-oxo-7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-3-yl}methyl)amino]methyl}-4-phenylazetidin-2-one
  • 5-(fluorosulfonyl)-2,3-dihydro-1H-indene-2-carboxylic acid
  • 5-{4-[(Tert-butoxy)carbonyl]piperazin-1-yl}-3-[(fluorosulfonyl)oxy]-2-methylbenzoic acid
  • N-(3-amino-4-methylpentyl)-N-methyl-3,4-dihydro-2H-1,5-benzodioxepine-6-carboxamide hydrochloride
  • tert-butyl N-(3-hydroxypropyl)-N-(4-methoxyphenyl)carbamate
  • Tert-butyl 3-hydroxy-8-methyl-1,8-diazaspiro[4.5]decane-1-carboxylate
  • rac-methyl (1R,3R)-1-{[(tert-butoxy)carbonyl]amino}-3-hydroxyspiro[3.3]heptane-1-carboxylate
  • tert-butyl N-(2,2-dimethoxyethyl)-N-(2-hydroxyethyl)carbamate
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