2-Chlorophenothiazine

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Names

[ CAS No. ]:
92-39-7

[ Name ]:
2-Chlorophenothiazine

[Synonym ]:
EINECS 202-152-5
10H-Phenothiazine, 2-chloro-
2-Chloro-10H-phenothiazine
MFCD00005016

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
395.7±31.0 °C at 760 mmHg

[ Melting Point ]:
195-200 °C(lit.)

[ Molecular Formula ]:
C12H8ClNS

[ Molecular Weight ]:
233.717

[ Flash Point ]:
193.1±24.8 °C

[ Exact Mass ]:
233.006592

[ PSA ]:
37.33000

[ LogP ]:
5.18

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.680

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SN7580000
CHEMICAL NAME :
Phenothiazine, 2-chloro-
CAS REGISTRY NUMBER :
92-39-7
LAST UPDATED :
199701
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C12-H8-Cl-N-S
MOLECULAR WEIGHT :
233.72
WISWESSER LINE NOTATION :
T C666 BM ISJ EG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
18 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Mutation test systems - not otherwise specified
TEST SYSTEM :
Bacteria - Escherichia coli
DOSE/DURATION :
160 mg/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 26,1205,1977

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36-S37/39

[ RIDADR ]:
UN 2811 6.1/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
SN7580000

[ Hazard Class ]:
6.1

[ HS Code ]:
2934300000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 1-Bromo-2-iodobenzene
  • 2-Amino-4-chlorothiophenol
  • Cyclohexanone
  • 2-Bromochlorobenzene
  • 1,2-Dibromobenzene
  • 1-Chloro-2-iodobenzene
  • 2-(2-bromo-phenylsulfanyl)-5-chloro-aniline
  • 3-Chlorodiphenylamine
  • acetic acid-[2-(5-chloro-2-nitro-phenylsulfanyl)-anilide]
  • 2-chloro-10-ethenylphenothiazine

DownStream

  • 10-[2-methyl-3-(methylamino)propyl]phenothiazine-2-carbonitrile
  • 2-Cyano-phenothiazine
  • Cyamemazine
  • Chlorpromazine
  • 2-chloro-10-methyl-10H-phenothiazine
  • 10-Allyl-2-chloro-10H-phenothiazine
  • 2-chloro-10H-phenothiazine 5-oxide
  • Phenothiazine
  • didemethylchlorpromazine
  • Phenothiazin-3-ol, 8-chloro-

Customs

[ HS Code ]: 2934300000

[ Summary ]:
2934300000. other compounds containing in the structure a phenothiazine ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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Related Compounds

  • 3-acetyl-2-chlorophenothiazine
  • 1-Acetyl-2-chlorophenothiazine
  • N-methyl-2-chlorophenothiazine
  • 2-Chlorophenothiazine sulfoxide
  • 10-Acryloyl-2-chlorophenothiazine
  • N-(formylmethyl)-2-chlorophenothiazine
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • N-[(2-Methyl-2,3-dihydro-1-benzofuran-5-yl)methyl]prop-2-enamide
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • N-(1,5-dimethyl-6-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-b]pyridin-3-yl)-4-(N,N-dimethylsulfamoyl)benzamide