2-Chlorophenothiazine

Modify Date: 2024-01-02 14:52:15

2-Chlorophenothiazine Structure
2-Chlorophenothiazine structure
Common Name 2-Chlorophenothiazine
CAS Number 92-39-7 Molecular Weight 233.717
Density 1.3±0.1 g/cm3 Boiling Point 395.7±31.0 °C at 760 mmHg
Molecular Formula C12H8ClNS Melting Point 195-200 °C(lit.)
MSDS Chinese USA Flash Point 193.1±24.8 °C
Symbol GHS07
GHS07
Signal Word Warning

 Names

Name 2-Chlorophenothiazine
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 395.7±31.0 °C at 760 mmHg
Melting Point 195-200 °C(lit.)
Molecular Formula C12H8ClNS
Molecular Weight 233.717
Flash Point 193.1±24.8 °C
Exact Mass 233.006592
PSA 37.33000
LogP 5.18
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.680

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SN7580000
CHEMICAL NAME :
Phenothiazine, 2-chloro-
CAS REGISTRY NUMBER :
92-39-7
LAST UPDATED :
199701
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C12-H8-Cl-N-S
MOLECULAR WEIGHT :
233.72
WISWESSER LINE NOTATION :
T C666 BM ISJ EG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
18 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Mutation test systems - not otherwise specified
TEST SYSTEM :
Bacteria - Escherichia coli
DOSE/DURATION :
160 mg/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 26,1205,1977

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S36-S37/39
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS SN7580000
Hazard Class 6.1
HS Code 2934300000

 Synthetic Route

 Customs

HS Code 2934300000
Summary 2934300000. other compounds containing in the structure a phenothiazine ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles8

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Glioblastoma multiforme (GBM), like most cancers, possesses a unique bioenergetic state of aerobic glycolysis known as the Warburg effect. Here, we documented that methylene blue (MB) reverses the War...

Broad specific enzyme-linked immunosorbent assay for determination of residual phenothiazine drugs in swine tissues.

Anal. Biochem. 454 , 7-13, (2014)

In this study, a novel generic hapten of phenothiazine drugs was synthesized by derivatization of 2-chlorophenothiazine with sodium bromoacetate. Then the hapten was coupled to bovine serum albumin fo...

N-benzoylated phenoxazines and phenothiazines: synthesis, antiproliferative activity, and inhibition of tubulin polymerization.

J. Med. Chem. 54 , 4247-63, (2011)

A total of 53 N-benzoylated phenoxazines and phenothiazines, including their S-oxidized analogues, were synthesized and evaluated for antiproliferative activity, interaction with tubulin, and cell cyc...

 Synonyms

EINECS 202-152-5
10H-Phenothiazine, 2-chloro-
2-Chloro-10H-phenothiazine
MFCD00005016
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