Methyleugenol
Suppliers
Names
[ CAS No. ]:
93-15-2
[ Name ]:
Methyleugenol
[Synonym ]:
EINECS 202-223-0
FEMA 2475
1U2R CO1 DO1
methyl eugenol
4-Allylveratrole
1,2-dimethoxy-4-(2-propen-1-yl)benzene
1,3,4-eugenol methyl ether
O-Methyl eugenol
LEVO-ROSE OXIDE
Eugenol methyl ether
4-Allyl-1,2-dimethoxybenzene
3,4-dimethoxyallylbenzene
3-METHYLEUGENOL
1-allyl-3,4-dimethoxybenzene
Allyl veratrole
femanumber2475
O-Methyleugenol
Eugenyl methyl ether
1,2-dimethoxy-4-(prop-2-en-1-yl)benzene
Methyleugenol
Benzene, 1,2-dimethoxy-4-(2-propen-1-yl)-
MFCD00008652
1-(3,4-Dimethoxyphenyl)-2-propene
4-Allylveratrol
Chemical & Physical Properties
[ Density]:
1.0±0.1 g/cm3
[ Boiling Point ]:
254.7±0.0 °C at 760 mmHg
[ Melting Point ]:
−4 °C(lit.)
[ Molecular Formula ]:
C11H14O2
[ Molecular Weight ]:
178.228
[ Flash Point ]:
87.1±22.7 °C
[ Exact Mass ]:
178.099380
[ PSA ]:
18.46000
[ LogP ]:
2.97
[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C
[ Index of Refraction ]:
1.500
[ Stability ]:
Stable. Combustible. Incompatible with strong oxidizing agents.
[ Water Solubility ]:
insoluble
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- CY2450000
- CHEMICAL NAME :
- Benzene, 4-allyl-1,2-dimethoxy-
- CAS REGISTRY NUMBER :
- 93-15-2
- BEILSTEIN REFERENCE NO. :
- 1910871
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 16
- MOLECULAR FORMULA :
- C11-H14-O2
- MOLECULAR WEIGHT :
- 178.25
- WISWESSER LINE NOTATION :
- 1U2R CO1 DO1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 810 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >4800 mg/m3
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 540 mg/kg
- TOXIC EFFECTS :
- Behavioral - changes in motor activity (specific assay) Behavioral - somnolence (general depressed activity) Behavioral - altered sleep time (including change in righting reflex)
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 112 mg/kg
- TOXIC EFFECTS :
- Behavioral - changes in motor activity (specific assay) Behavioral - somnolence (general depressed activity) Behavioral - altered sleep time (including change in righting reflex)
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- >2025 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4200 mg/kg/6W-I
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- Unscheduled DNA synthesis
MUTATION DATA
- TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 80 mg/kg
- REFERENCE :
- CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 5,1613,1984 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 04500 No. of Facilities: 41 (estimated) No. of Industries: 2 No. of Occupations: 21 No. of Employees: 2840 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 04500 No. of Facilities: 1074 (estimated) No. of Industries: 5 No. of Occupations: 10 No. of Employees: 12682 (estimated) No. of Female Employees: 9413 (estimated)
Safety Information
[ Symbol ]:
GHS07, GHS08, GHS09
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302-H315-H319-H335-H351-H411
[ Precautionary Statements ]:
P280-P301 + P312 + P330-P305 + P351 + P338
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
Xn:Harmful
[ Risk Phrases ]:
R22;R36/37/38;R40
[ Safety Phrases ]:
S26-S36/37/39
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
1
[ RTECS ]:
CY2450000
[ HS Code ]:
29093090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2909309090
[ Summary ]:
2909309090 other aromatic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%
Articles
Food Chem. Toxicol. 74 , 28-34, (2014)
The alkenylbenzene methyleugenol occurs naturally in a variety of spices and herbs, including basil, and their essential oils. At high dose levels methyleugenol induces hepatocarcinogenicity in rodent...
Toxicol. Appl. Pharmacol. 283(2) , 117-26, (2015)
The present study aims at predicting the level of formation of the ultimate carcinogenic metabolite of methyleugenol, 1'-sulfooxymethyleugenol, in the human population by taking variability in key bio...
Bioorg. Med. Chem. Lett. 15 , 1949-53, (2005)
1'S-1'-Acetoxychavicol acetate from the rhizomes of Alpinia galanga inhibited nitric oxide (NO) production in lipopolysaccharide-activated mouse peritoneal macrophages with an IC(50) value of 2.3 micr...