Mecoprop

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Names

[ CAS No. ]:
93-65-2

[ Name ]:
Mecoprop

[Synonym ]:
2-MCPP
EINECS 202-264-4
Propanoic acid,2-(4-chloro-2-methylphenoxy)-
2-(4-Chloro-2-methylphenoxy)propanoic acid
MFCD00002648
UNII:74N8TKR9P8
COMPITOX
U 46
2M-4CP
Clonotox
Propal
MCPP
2M4KhP
Propanoic acid, 2-(4-chloro-2-methylphenoxy)-
Hymec
CMPP
2-(2-Methyl-4-chlorophenoxy)propionic acid
Mecoprop
Astix
Mepro
ACTRIL M
Anicon P

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
331.9±27.0 °C at 760 mmHg

[ Melting Point ]:
88-90ºC

[ Molecular Formula ]:
C10H11ClO3

[ Molecular Weight ]:
214.65

[ Flash Point ]:
154.5±23.7 °C

[ Exact Mass ]:
214.039673

[ PSA ]:
46.53000

[ LogP ]:
2.84

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.542

[ Storage condition ]:
APPROX 4°C

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UE9750000
CHEMICAL NAME :
Propionic acid, 2-((4-chloro-o-tolyl)oxy)-
CAS REGISTRY NUMBER :
93-65-2
BEILSTEIN REFERENCE NO. :
2212752
LAST UPDATED :
199710
DATA ITEMS CITED :
23
MOLECULAR FORMULA :
C10-H11-Cl-O3
MOLECULAR WEIGHT :
214.66
WISWESSER LINE NOTATION :
QVY1&OR DG B1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
650 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
402 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
369 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
650 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
900 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Bird - quail
DOSE/DURATION :
>500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
14400 mg/kg/90D-I
TOXIC EFFECTS :
Behavioral - food intake (animal) Blood - pigmented or nucleated red blood cells Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
15 gm/kg/3W-I
TOXIC EFFECTS :
Skin and Appendages - dermatitis, other (after systemic exposure) Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
7 gm/kg
SEX/DURATION :
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
3 gm/kg
SEX/DURATION :
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
5 gm/kg
SEX/DURATION :
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

MUTATION DATA

TEST SYSTEM :
Rodent - mouse
DOSE/DURATION :
100 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 55,197,1978 *** REVIEWS *** IARC Cancer Review:Human Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 41,357,1986 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,156,1987 TOXICOLOGY REVIEW DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970. Volume(issue)/page/year: 80,485,1973 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M4007 No. of Facilities: 40 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 104 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M4007 No. of Facilities: 263 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 1578 (estimated)

Safety Information

[ Hazard Codes ]:
Xn,N

[ Risk Phrases ]:
R22;R38;R41;

[ Safety Phrases ]:
S26;S37/S39

[ Hazard Class ]:
3.2

[ HS Code ]:
2918990022

Synthetic Route

Precursor & DownStream

Precursor

  • Sodium 4-chloro-2-methylphenolate
  • Ethyl (2S)-2-bromopropanoate

DownStream

  • [1-cyanoethyl(dimethyl)silyl] 2-(4-chloro-2-methylphenoxy)propanoate
  • 2-[2-[2-[2-[2-(4-chloro-2-methylphenoxy)propanoyloxy]ethoxy]ethoxy]ethoxy]ethyl 2-(4-chloro-2-methylphenoxy)propanoate
  • 2-(4-chloro-2-methyl-phenoxy)-N-phenyl-propanamide
  • mecoprop-p
  • (S)-mecoprop

Customs

[ HS Code ]: 2918990022

[ Summary ]:
2918990022 2-(4-chloro-2-methylphenoxy)acetic acid。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:30.0%


Related Compounds

  • Mecoprop
  • Mecoprop-P
  • mecoprop-p
  • MECOPROP-P
  • mecoprop-P
  • Mecoprop-d6