azetidinone

Names

[ CAS No. ]:
930-21-2

[ Name ]:
azetidinone

[Synonym ]:
azetidinone
2-AZACYCLOBUTANONE
2-oxoazetidine
MFCD00013328
AZETAN-2-ONE
2-Azetidinone
Azetidin-2-one
4-oxo-azetidine
Propiolactam

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
222.4±0.0 °C at 760 mmHg

[ Melting Point ]:
74-76 °C(lit.)

[ Molecular Formula ]:
C₃H₅NO

[ Molecular Weight ]:
71.078

[ Flash Point ]:
151.5±3.4 °C

[ Exact Mass ]:
71.037117

[ PSA ]:
29.10000

[ LogP ]:
-2.02

[ Vapour Pressure ]:
0.1±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.458

[ Storage condition ]:
2-8°C

MSDS

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
C: Corrosive;

[ Risk Phrases ]:
R34

[ Safety Phrases ]:
S26-S36/37/39-S45

[ RIDADR ]:
UN 3263 8/PG 2

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ Hazard Class ]:
8

[ HS Code ]:
2933790090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

beta-Alanine
4-Acetoxy-2-azetidinone
Methyl β-alaninate
1-aminoazetidin-2-one
1-isopropylazetidin-2-one
2-Azetidinone,1-methyl-
1-(4-methylphenyl)sulfonylazetidin-2-one
Ethyl β-alaninate
ETHYLMAGNESIUM BROMIDE
(4R)-4-phenylthio-2-azetidinone

DownStream

3-Nitropropanoic acid
6-Nitro-2H-1,4-benzoxazin-3(4H)-one
4-Acetoxy-2-azetidinone
1-chloroazetidin-2-one
1,3,4,5-Tetrahydro-2H-1,5-benzodiazepin-2-one
2-Azetidinone,1-(2-aminophenyl)-(9CI)
beta-Alanine
(3R,4S)-4-Phenyl-3-[(Triethylsilyl)Oxy]-2-Azetidinone
1-(4-methylphenyl)sulfonylazetidin-2-one
TERT-BUTYL 2-OXOAZETIDINE-1-CARBOXYLATE

Customs

[ HS Code ]: 2933790090

[ Summary ]:
2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%

Articles

The influence of ezetimibe on classical and alternative activation pathways of monocytes/macrophages isolated from patients with hypercholesterolemia.

Naunyn Schmiedebergs Arch. Pharmacol. 387(8) , 733-42, (2014)

Macrophages are crucial for the development of atherosclerotic plaques. Classically activated macrophages contribute to plaque growth and destabilization, while alternatively activated macrophages inc...

Non-transpeptidase binding arylthioether β-lactams active against Mycobacterium tuberculosis and Moraxella catarrhalis.

Bioorg. Med. Chem. 23(3) , 632-47, (2015)

The prevalence of drug resistance in both clinical and community settings as a consequence of alterations of biosynthetic pathways, enzymes or cell wall architecture is a persistent threat to human he...

Photoelectron spectra of some antibiotic building blocks: 2-azetidinone and thiazolidine-carboxylic acid.

J. Phys. Chem. A 116(33) , 8653-60, (2012)

X-ray photoelectron spectra of the core and valence levels of the fundamental building blocks of β-lactam antibiotics have been investigated and compared with theoretical calculations. The spectra of ...

azetidinone
azetidinone
3-Azetidinone
3-AZETIDINONE HCL
amino-azetidinone
3-aminoazetidinone
2,2-Dichloro-1-(3-chloro-5-methoxyphenyl)ethanol
2-Amino-2-(4-{[(tert-butoxy)carbonyl]amino}-2-fluorophenyl)acetic acid
tert-butyl N-[2-(1-hydroxy-2-methylpropan-2-yl)-5-(trifluoromethyl)phenyl]carbamate
4-(Azetidin-3-yl)-2-methylquinoline
tert-butyl N-[4-(2,5-dioxooxolan-3-yl)-3-methoxyphenyl]carbamate
N-[1-(5-bromo-3-chloropyridin-2-yl)piperidin-3-yl]cyclopropanesulfonamide
2-[4-(9-ethyl-9H-purin-6-yl)piperazin-1-yl]-1-(4-phenylpiperazin-1-yl)ethan-1-one
4-Ethyl-1-(3-methyl-1,2-thiazol-5-yl)cyclohex-2-en-1-ol
N-(3-methylphenyl)-2-[4-(1,3-thiazol-2-yloxy)piperidin-1-yl]acetamide
2-[4-(cyclopropanesulfonyl)-1,4-diazepan-1-yl]-N-(prop-2-en-1-yl)acetamide

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