4-Phenylpyridine

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Names

[ CAS No. ]:
939-23-1

[ Name ]:
4-Phenylpyridine

[Synonym ]:
4-AZABIPHENYL
Pyridine,4-phenyl
4-phenyl-pyridine
4-Phenylpyridine
4-Pyridylbenzene
4-phenyl-pyridin
4-Aza-1,1'-biphenyl
EINECS 213-357-4
MFCD00006420
4-phenyl pyridine
phenylpyridine
Pyridine, 4-phenyl-
p-Phenylpyridine

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
281.0±0.0 °C at 760 mmHg

[ Melting Point ]:
69-73 °C(lit.)

[ Molecular Formula ]:
C11H9N

[ Molecular Weight ]:
155.196

[ Flash Point ]:
111.1±11.4 °C

[ Exact Mass ]:
155.073502

[ PSA ]:
12.89000

[ LogP ]:
2.59

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.576

[ Storage condition ]:
Refrigerator

[ Water Solubility ]:
SOLUBLE

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UT7141000
CHEMICAL NAME :
Pyridine, 4-phenyl-
CAS REGISTRY NUMBER :
939-23-1
BEILSTEIN REFERENCE NO. :
0110490
LAST UPDATED :
199710
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C11-H9-N
MOLECULAR WEIGHT :
155.21
WISWESSER LINE NOTATION :
T6NJ DR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
89 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
650 umol/L/2H
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 39,4152,1979

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
UT7141000

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-chloropyridine
  • Phenylboronic acid
  • Iodobenzene
  • Pyridine-4-boronic acid
  • 4-Bromo-pyridine HCl
  • Bromobenzene
  • 4-Bromopyridine
  • 1-ethoxycarbonyl-4-phenyl-1,4-dihydropyridine
  • 4-Chloropyridinium chloride
  • 4-Phenylpyridine 1-oxide

DownStream

  • 4-Phenylpyridin-2-amine
  • 5-Bromooxindole
  • 4-phenyl-2,6-bis(4-phenylpyridin-2-yl)pyridine
  • 1-(2,4-dinitrophenyl)-4-phenylpyridin-1-ium,chloride
  • 4-Phenylpiperidine
  • 4,4'-DIPHENYL-2,2'-BIPYRIDINE
  • 2-Bromo-4-phenylpyridine
  • Isonicotinic acid
  • 4-Phenylpyridine 1-oxide
  • 4-Cyclohexylpiperidine

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

cIEF for rapid pKa determination of small molecules: a proof of concept.

Eur. J. Pharm. Sci. 63 , 14-21, (2014)

A capillary isoelectric focusing (cIEF) method was developed for the determination of the ionization constants (pKa) of small molecules. Two approaches used to decrease the electroosmotic flow (EOF) w...

Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).

J. Med. Chem. 48 , 3269-79, (2005)

Growing interest in the use of both the logarithm of the partition coefficient of the neutral species in the alkane/water system (log P(N)(alk)) and the difference between log P(N)(oct) (the logarithm...

4-phenylpyridine and three other analogues of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine lack dopaminergic nigrostriatal neurotoxicity in mice and marmosets.

Neurosci. Lett. 75(1) , 65-70, (1987)

C57 black mice were injected repeatedly with maximal tolerated doses of 2 chemical analogues of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP); 4-phenylpyridine and 4-phenyl-1,2,3,6-tetrahydropyr...


More Articles

Related Compounds

  • 4-Phenylpyridine 1-oxide
  • 2-Bromo-4-phenylpyridine
  • 3-Amino-4-phenylpyridine
  • 3-Nitro-4-phenylpyridine
  • 2-cyano-4-phenylpyridine
  • 3-bromo-4-phenylpyridine
  • 3-[5-(bromomethyl)-1H-pyrazol-1-yl]benzonitrile
  • [1-(2-chloro-4-fluorophenyl)-1H-pyrazol-5-yl]methanamine
  • 3-[(cyclopropylamino)methyl]-5-fluoro-1-methyl-1H-indole-2-carbonitrile
  • 2-[1-(3-hydroxybutyl)-5-propyl-1H-1,2,3-triazol-4-yl]acetic acid
  • 2-(1-{[1-(hydroxymethyl)cyclopropyl]methyl}-5-(propan-2-yl)-1H-1,2,3-triazol-4-yl)acetic acid
  • 4,4,4-Tribromo-2,2-difluoro-3-hydroxybutanoic acid
  • tert-butyl 5-(aminomethyl)-1H-1,2,4-triazole-3-carboxylate
  • 5-(4-Bromophenoxy)-2-hydrazinylpyrimidine
  • Benzyl 4-(aminomethyl)-2,5-dimethylpiperidine-1-carboxylate
  • Tert-butyl 4-(aminomethyl)-2,5-dimethylpiperidine-1-carboxylate
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