4-Phenylpyridine
4-Phenylpyridine structure
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Common Name | 4-Phenylpyridine | ||
|---|---|---|---|---|
| CAS Number | 939-23-1 | Molecular Weight | 155.196 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 281.0±0.0 °C at 760 mmHg | |
| Molecular Formula | C11H9N | Melting Point | 69-73 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 111.1±11.4 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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cIEF for rapid pKa determination of small molecules: a proof of concept.
Eur. J. Pharm. Sci. 63 , 14-21, (2014) A capillary isoelectric focusing (cIEF) method was developed for the determination of the ionization constants (pKa) of small molecules. Two approaches used to decrease the electroosmotic flow (EOF) were compared: (i) a hydroxypropylcellulose (HPC) coated cap... |
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Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
J. Med. Chem. 48 , 3269-79, (2005) Growing interest in the use of both the logarithm of the partition coefficient of the neutral species in the alkane/water system (log P(N)(alk)) and the difference between log P(N)(oct) (the logarithm of the partition coefficient of the neutral species in the... |
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4-phenylpyridine and three other analogues of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine lack dopaminergic nigrostriatal neurotoxicity in mice and marmosets.
Neurosci. Lett. 75(1) , 65-70, (1987) C57 black mice were injected repeatedly with maximal tolerated doses of 2 chemical analogues of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP); 4-phenylpyridine and 4-phenyl-1,2,3,6-tetrahydropyridine. Although both compounds were clearly acutely toxic t... |
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Simple chip-based interfaces for on-line monitoring of supramolecular interactions by nano-ESI MS.
Lab Chip 5(10) , 1111-22, (2005) Two simple interfaces were designed and realized, enabling on-line coupling of microfluidics reactor chips to a nanoflow electrospray ionization (NESI) time-of-flight (TOF) mass spectrometer (MS). The interfaces are based on two different approaches: a monoli... |
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Potentiation of MPTP by 4-phenylpyridine on the neuromuscular blockade in mouse phrenic nerve-diaphragm.
Neuropharmacology 32(9) , 877-83, (1993) Potentiation by 4-phenylpyridine (a MAO-B inhibitor) on the neuromuscular blocking action of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) was studied in mouse phrenic nerve-diaphragm. MPTP blocked nerve-evoked twitches in a concentration (1-200 microM)... |
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Inhibition of uptake of 1-methyl-4-phenylpyridinium ion and dopamine in striatal synaptosomes by tobacco smoke components.
Eur. J. Pharmacol. 215(2-3) , 285-7, (1992) To determine whether the attenuation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity by tobacco smoke exposure is caused by inhibition of the neuronal uptake of 4-phenylpyridinium ion (MPP+), various tobacco components and a smoke... |
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L-deprenyl (selegiline) limits the repetitive firing of action potentials in rat hippocampal CA1 neurons via a dopaminergic mechanism.
Brain Res. 753(1) , 27-35, (1997) The effects of L-deprenyl (selegiline), a highly selective monoamine oxidase type B (MAO-B) inhibitor, on cell excitability of rat hippocampal CA1 neurons were examined in slice preparations using intracellular recording techniques. Superfusion of L-deprenyl ... |
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Vibrational spectroscopic study on some Hofmann-Td type clathrates: Ni(4-phenylpyridine)2M(CN)4·2G (M=Cd or Hg, G=1,4-dioxane).
Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 78(5) , 1487-91, (2011) New Hofmann-T(d) type clathrates in the form of Ni(4-Phpy)(2)M(CN)(4)·2G (where 4-Phpy=4-phenylpyridine, M=Cd or Hg and G=1,4-dioxane) have been prepared in powder form and their FT-IR and Raman spectra have been reported. The results suggest that these compo... |
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Behavioral and biochemical effects of 4-phenylpyridine, 2-phenylpyridine, and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in rodents.
Adv. Neurol. 53 , 219-23, (1990)
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Synthesis, characterization and cytotoxic activities of the [RuCl2(NO)(dppp)(L)]PF6 complexes.
J. Inorg. Biochem. 104(5) , 489-95, (2010) The synthesis and characterization of ruthenium compounds of the type [RuCl(2)(NO)(dppp)(L)]PF(6) [dppp=1,3-bis(diphenylphosphino)propane; L=pyridine, 4-methylpyridine, 4-phenylpyridine and dimethyl sulfoxide] are described. The complexes were characterized b... |