salicylaldehyde, oxime

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Names

[ CAS No. ]:
94-67-7

[ Name ]:
salicylaldehyde, oxime

[Synonym ]:
2-hydroxybenzaldehyde oxime
salicylaldehyde, oxime
Saldox
Benzaldehyde, 2-hydroxy-, oxime
SALICYLALDEHYDE OXIME
Salicylaldehydoxime
2-hydroxybenzaldoxime
SalicyladoximeGr
o-Hydroxybenzaldoxime
MFCD00002120
o-hydroxybenzaldehyde oxime
EINECS 202-353-8
2-[(Hydroxyimino)methyl]phenol
Salicaldehyde oxime
2-[(E)-(Hydroxyimino)methyl]phenol

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
256.5±23.0 °C at 760 mmHg

[ Melting Point ]:
59-61 °C(lit.)

[ Molecular Formula ]:
C7H7NO2

[ Molecular Weight ]:
137.136

[ Flash Point ]:
146.9±11.9 °C

[ Exact Mass ]:
137.047684

[ PSA ]:
52.82000

[ LogP ]:
1.88

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.552

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VN5775000
CHEMICAL NAME :
Salicylaldehyde, oxime
CAS REGISTRY NUMBER :
94-67-7
BEILSTEIN REFERENCE NO. :
1859881
LAST UPDATED :
199712
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C7-H7-N-O2
MOLECULAR WEIGHT :
137.15
WISWESSER LINE NOTATION :
QNU1R BQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC) Volume(issue)/page/year: 5,36,1953

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
VN5775000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Salicylaldehyde
  • 2-Methylbenzyl Alcohol
  • salicyl alcohol
  • Phenol
  • N'-(2-hydroxybenzylidene)-2-imino-2H-chromene-3-carbohydrazide
  • Formaldehyde
  • 2-(acetoxyiminomethyl)phenol
  • hexanoylsalicylaldoxime

DownStream

  • 2-ETHOXYCHROMAN
  • 2'-Hydroxy-3-phenylpropiophenone
  • 2-(((2-hydroxybenzyl)amino)methyl)phenol
  • 2-(1H-TETRAZOL-5-YL)PHENOL
  • 2-Ethoxybenzamide
  • FLAVANONE
  • alpha-ethoxy-ortho-cresol
  • 6-(5-phenyl-1,2-oxazolidin-3-ylidene)cyclohexa-2,4-dien-1-one
  • 2-Cyanophenol
  • 1,2-BENZISOXAZOLE

Articles

Selective and potent agonists for estrogen receptor beta derived from molecular refinements of salicylaldoximes.

Eur. J. Med. Chem. 46 , 2453-62, (2011)

In a continuing effort to improve the subtype selectivity and agonist potency of estrogen receptor β (ERβ) ligands, we have designed and developed a thus far unexplored structural series obtained by m...

Structural evolutions of salicylaldoximes as selective agonists for estrogen receptor beta.

J. Med. Chem. 52 , 858-67, (2009)

The bioisosteric replacement of the phenol ring, a signature functional group of most estrogen receptor (ER) ligands, with a hydrogen-bonded pseudocyclic ring, led to the development of a novel class ...

Linking [M(III)3] triangles with "double-headed" phenolic oximes.

Dalton Trans. 41(29) , 8777-85, (2012)

Strapping two salicylaldoxime units together with aliphatic α,Ω-aminomethyl links in the 3-position gives ligands which allow the assembly of the polynuclear complexes [Fe(7)O(2)(OH)(6)(H(2)L1)(3)(py)...


More Articles

Related Compounds

  • 3-trifluoromethyl-5-tert-butyl salicylaldehyde oxime
  • N-[(2-prop-2-enoxyphenyl)methylidene]hydroxylamine
  • 4-chloro-6-[(hydroxyamino)methylidene]cyclohexa-2,4-dien-1-one
  • salicylaldehyde-(N-benzyl oxime )
  • salicylaldehyde-(O-benzoyl oxime )
  • salicylaldehyde-(N-carbamoyl oxime )
  • 2-(Oxolan-2-ylmethyl)-4,5,6,7-tetrahydropyrazolo[3,4-c]pyridine;hydrochloride
  • Lithium;4,5,6,7-tetrahydrotriazolo[1,5-a]pyridine-7-carboxylate
  • Tert-butyl 4-(4-chlorophenyl)-2,4-dioxobutanoate
  • 4-(2,3-Dihydro-1,4-benzodioxin-6-ylmethylidene)piperidine hydrochloride
  • 4-(2,3-Dihydro-1,4-benzodioxin-6-ylmethyl)piperidine hydrochloride
  • 1-(5-Methyl-1,3,4-oxadiazol-2-yl)piperidin-4-amine dihydrochloride
  • N,N-Dimethyl-1-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophen-2-yl)methanamine
  • 4-cyclopropyl-1-{[(2S)-pyrrolidin-2-yl]methyl}-1H-1,2,3-triazole
  • 2-Methyl-2-(methylamino)propanamide hydrochloride
  • (2R,5S)-2,5-dimethyl-3-(2,2,2-trifluoroethyl)pyrrolidine hydrochloride
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