4-iodo-N-[(3S)-tetrahydro-2-oxo-3-furanyl]-Benzeneacetamide

[ Molecular Formula ]:
C₁₂H₁₂INO₃

[ Molecular Weight ]:
345.13

[ Storage condition ]:
−20°C

[ RIDADR ]:
NONH for all modes of transport

Attenuation of quorum sensing in the pathogen Acinetobacter baumannii using non-native N-Acyl homoserine lactones.

ACS Chem. Biol. 7(10) , 1719-28, (2012)

Many bacterial pathogens use quorum sensing (QS) to control virulence. As a result, the development of methods to intercept QS has attracted significant interest as a potential anti-infective therapy....

Modulation of bacterial quorum sensing with synthetic ligands: systematic evaluation of N-acylated homoserine lactones in multiple species and new insights into their mechanisms of action.

J. Am. Chem. Soc. 129(44) , 13613-25, (2007)

Bacteria use a language of low molecular weight ligands to assess their population densities in a process called quorum sensing. This chemical signaling process plays a pivotal role both in the pathog...

Small molecule disruption of quorum sensing cross-regulation in pseudomonas aeruginosa causes major and unexpected alterations to virulence phenotypes.

J. Am. Chem. Soc. 137(4) , 1510-9, (2015)

The opportunistic pathogen Pseudomonas aeruginosa uses three interwoven quorum-sensing (QS) circuits-Las, Rhl, and Pqs-to regulate the global expression of myriad virulence-associated genes. Intercept...

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