2,4-Dichlorotoluene

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Names

[ CAS No. ]:
95-73-8

[ Name ]:
2,4-Dichlorotoluene

[Synonym ]:
2,4-Dichlorotoluene
2,4-Dichlor-toluol
2,4-dichloro-1-methyl-benzene
2,4-Dichloro-1-methylbenzene
EINECS 202-445-8
2,4-dichloro-toluene
Benzene, 2,4-dichloro-1-methyl-
4,6-dichlorothieno<2,3-b>pyridine
MFCD00000583
4,6-dichlorotoluene

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
198.6±20.0 °C at 760 mmHg

[ Melting Point ]:
-14 °C

[ Molecular Formula ]:
C₇H₆Cl₂

[ Molecular Weight ]:
161.029

[ Flash Point ]:
79.4±0.0 °C

[ Exact Mass ]:
159.984650

[ LogP ]:
3.88

[ Vapour Pressure ]:
0.5±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.543

[ Water Solubility ]:
immiscible

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XT0730000

CHEMICAL NAME :: Toluene, 2,4-dichloro-

CAS REGISTRY NUMBER :: 95-73-8

BEILSTEIN REFERENCE NO. :: 1931691

LAST UPDATED :: 199710

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C7-H6-Cl2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2400 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - muscle weakness

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 25(10),56,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2400 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - muscle weakness

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 25(10),56,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 53(2),80,1988 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6440 mg/kg/2W-I

TOXIC EFFECTS :: Liver - other changes Blood - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 52(11),86,1987

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 28980 mg/kg/9W-I

TOXIC EFFECTS :: Liver - fatty liver degeneration Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 53(2),80,1988

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S23-S24/25

[ RIDADR ]:
UN 2810

[ WGK Germany ]:
2

[ RTECS ]:
XT0730000

[ Packaging Group ]:
III

[ Hazard Class ]:
9

[ HS Code ]:
29036990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Toluene
4-Chlorotoluene
Benzenemethanethiol,2,4-dichloro-
2,4-Dichlorobenzoic acid
4-methylphenyltellurium trichloride
1-Bromo-2,4-dichlorobenzene
Dimethylzinc
2,4-Dichloro-1-(trifluoromethyl)benzene
2,4-Diaminotoluene
2-Chlorotoluene

DownStream

2,4,5-Trichlorobenzoic Acid
2,4-Dichlorobenzoic acid
2,4-Dichlorobenzyl chloride
2-Methylbenzoic acid
3-Chloro-4-methylbenzoic acid
5-Chloro-2-methylbenzoic acid
4-Methylbenzoic acid
2-Chlorotoluene
2-methylbenzophenone
4-methylbenzene-1,3-dicarbonitrile

Customs

[ HS Code ]: 2903999090

[ Summary ]:
2903999090 halogenated derivatives of aromatic hydrocarbons VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Articles

Metabolism of dichloromethylcatechols as central intermediates in the degradation of dichlorotoluenes by Ralstonia sp. strain PS12.

J. Bacteriol. 184(19) , 5261-74, (2002)

Ralstonia sp. strain PS12 is able to use 2,4-, 2,5-, and 3,4-dichlorotoluene as growth substrates. Dichloromethylcatechols are central intermediates that are formed by TecA tetrachlorobenzene dioxygen...

Development of a solid-phase microextraction-gas chromatography-tandem mass spectrometry method for the analysis of chlorinated toluenes in environmental waters.

J. Chromatogr. A. 1216(14) , 2816-24, (2009)

In the present work, a simple and fast methodology has been developed for the analysis of chlorotoluenes in water samples using solid-phase microextraction (SPME) coupled to gas chromatography-tandem ...

Rapid and selective catalytic oxidation of secondary alcohols at room temperature by using (N-heterocyclic carbene)-ni(0) systems.

Chemistry 16(23) , 6857-60, (2010)

The selective, anaerobic catalytic oxidation of secondary alcohols at room temperature by using an in situ (N-heterocyclic carbene)-Ni(0) system is presented. The use of non-anhydrous, non-degassed 2,...