2'-deoxyuridine

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Names

[ CAS No. ]:
951-78-0

[ Name ]:
2'-deoxyuridine

[Synonym ]:
Uracildeoxyr
deoxyuridine
1-(2-Deoxy-β-D-erythro-pentofuranosyl)-4-hydroxy-2(1H)-pyrimidinone
T6NVMVJ A- ET5OTJ B1Q CQ &&Ribo-β-D Form
2'-deoxy-uridin
2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-β-D-erythro-pentofuranosyl)-
1-(2-Deoxy-b-D-erythro-pentofuranosyl)uracil
[131I]-Deoxyuridine
2'-Deoxyuridine
Desoxyuridine
Uridine, 2'-deoxy-
MFCD00006527
2'-dU
EINECS 213-455-7
1-(2-Deoxy-D-erythro-pentofuranosyl)uracil
Deoxyribose uracil
1-(2-deoxy-β-D-ribofuranosyl)-2,4(1H,3H)-Pyrimidinedione
Deoxy-uridin
2′-Deoxyuridine
2(1H)-Pyrimidinone, 1-(2-deoxy-β-D-erythro-pentofuranosyl)-4-hydroxy-
[3H]-Deoxyuridine
1-(2-deoxy-β-D-erythro-pentofuranosyl)uracil
1-(2-deoxy-β-δ-erythro-pentofuranosyl)-2,4(1H,3H)-Pyrimidinedione
1-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
durd
2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-β-D-ribofuranosyl)-
1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-2,4(1H,3H)-pyrimidinedione
1-(2-deoxy-β-δ-ribofuranosyl)-2,4(1H,3H)-Pyrimidinedione
DEOXYURIDINE-2'
1-(2-deoxy-β-D-erythro-pentofuranosyl)-2,4(1H,3H)-Pyrimidinedione
1-(2-Deoxy-β-D-erythro-pentofuranosyl)pyrimidin-2,4(1H,3H)-dion
2'-DEOXYTHYMIDINE-5'-DIPHOSPHATE TRISODIUM SALT
1-(2-Deoxy-δ-erythro-pentofuranosyl)uracil

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Melting Point ]:
167-169 °C(lit.)

[ Molecular Formula ]:
C9H12N2O5

[ Molecular Weight ]:
228.202

[ Exact Mass ]:
228.074615

[ PSA ]:
104.55000

[ LogP ]:
-1.70

[ Index of Refraction ]:
1.603

[ Storage condition ]:
0-6°C

[ Water Solubility ]:
300 g/L (20 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YU7490000
CHEMICAL NAME :
Uridine, 2'-deoxy-
CAS REGISTRY NUMBER :
951-78-0
BEILSTEIN REFERENCE NO. :
0024433
LAST UPDATED :
199701
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C9-H12-N2-O5
MOLECULAR WEIGHT :
228.23

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
Mutation in mammalian somatic cells
TEST SYSTEM :
Rodent - hamster Lung
DOSE/DURATION :
1 mmol/L
REFERENCE :
BICMBE Biochimie. (SPPIF, B.P.22, F-41353 Vineuil, France) V.53- 1971- Volume(issue)/page/year: 64,809,1982

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S22-S24/25-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
YU7490000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Broxuridine
  • 3',5'-Bis-O-(tert-butyldimethylsilyl)-2'-deoxyuridine
  • idoxuridine
  • 3',5'-O-(tetraisopropyl-disiloxane-1,3-diyl)-2'-O-phenoxythiocarbonyl-uridine
  • Uridine
  • 5'-Trt-2'-dU
  • 3',5'-O-(1,1,3,3-TETRAISOPROPYL-1,3-DISILOXANEDIYL)URIDINE
  • 1-{4-hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydrofuran-2-yl}-1H-pyrimidine-2,4-dione

DownStream

  • 2,6-Dichloropurine-2'-deoxyriboside
  • 5-Chloro-2'-deoxyuridine
  • idoxuridine
  • Uracil
  • Floxuridine
  • (5S,6R)-5-fluoro-6-hydroxy-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)dihydropyrimidine-2,4(1H,3H)-dione
  • (4R,5S)-5-fluoro-3-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2,6-dioxohexahydropyrimidin-4-yl acetate
  • 2,6-Diaminopurine 2'-deoxyriboside
  • 2-Deoxy-D-ribose
  • 5'-Trt-2'-dU

Articles

Simultaneous quantification of purine and pyrimidine bases, nucleosides and their degradation products in bovine blood plasma by high performance liquid chromatography tandem mass spectrometry.

J. Chromatogr. A. 1356 , 197-210, (2014)

Improved nitrogen utilization in cattle is important in order to secure a sustainable cattle production. As purines and pyrimidines (PP) constitute an appreciable part of rumen nitrogen, an improved u...

Phase I study of oral gemcitabine prodrug (LY2334737) in Japanese patients with advanced solid tumors.

Cancer Chemother. Pharmacol. 71(6) , 1645-55, (2013)

LY2334737 is an oral gemcitabine prodrug. This Phase I study assessed the safety and tolerability of LY2334737 in Japanese patients with solid tumors and evaluated pharmacokinetics (PK), pharmacodynam...

Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

J. Med. Chem. 51 , 6740-51, (2008)

The work provides a new model for the prediction of the MAO-A and -B inhibitor activity by the use of combined complex networks and QSAR methodologies. On the basis of the obtained model, we prepared ...


More Articles

Related Compounds

  • 2'-Deoxyuridine-d2
  • 5--2'-deoxyuridine
  • 5--2'-deoxyuridine
  • 2'-Deoxyuridine-d2-1
  • 2'-Deoxyuridine-15N2
  • 2'-DEOXYURIDINE-5-3H
  • 5-Bromo-2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
  • LithiumN,N'-diphenyl-2,4-pentanediiminate
  • (5R,7S)-5-Cyclopropyl-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carbonitrile
  • Ethyl 3-(3-(((tert-butoxycarbonyl)amino)methyl)phenyl)propanoate
  • 7-(4-hydroxyphenyl)-2-(2-methoxyphenyl)-5-methyl-N-(pyridin-3-yl)-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxamide
  • Xjf8ymc8PW
  • ethyl 1-[[4-(N-ethoxycarbonylcarbamimidoyl)phenyl]methyl]-8-[(3-ethoxy-3-oxopropyl)-pyridin-2-ylcarbamoyl]-3,4-dihydro-1H-pyrazino[1,2-a]benzimidazole-2-carboxylate
  • benzyl 8-[(3-ethoxy-3-oxopropyl)-pyridin-2-ylcarbamoyl]-1-[[4-(N-phenylmethoxycarbonylcarbamimidoyl)phenyl]methyl]-3,4-dihydro-1H-pyrazino[1,2-a]benzimidazole-2-carboxylate
  • pentyl 8-[(3-ethoxy-3-oxopropyl)-pyridin-2-ylcarbamoyl]-1-[[4-(N-pentoxycarbonylcarbamimidoyl)phenyl]methyl]-3,4-dihydro-1H-pyrazino[1,2-a]benzimidazole-2-carboxylate
  • hexyl 8-[(3-ethoxy-3-oxopropyl)-phenylcarbamoyl]-1-[[4-(N-hexoxycarbonylcarbamimidoyl)phenyl]methyl]-3,4-dihydro-1H-pyrazino[1,2-a]benzimidazole-2-carboxylate
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