1,3-Dichloro-2-propanol
Suppliers
Names
[ CAS No. ]:
96-23-1
[ Name ]:
1,3-Dichloro-2-propanol
[Synonym ]:
1,3-dichloro-1,3-dideoxyglycerol
2-Propanol, 1,3-dichloro-
glycerol 1,3-dichlorohydrin
U 25,354
1,3-dichloro-2-hydroxypropane
EINECS 202-491-9
1,3-dichlorohydrin
DCP
gdch
1,3-DCP
Enodrin
1,3-di-chloro-2-propanol
1,3-dichloro-2-propyl alcohol
Dichlorohydrin
1,3-dichloropropan-2-ol
MFCD00000951
1,3-Dichloro-2-propanol
Glycerol-α,γ-dichlorohydrin
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Boiling Point ]:
174.3±0.0 °C at 760 mmHg
[ Melting Point ]:
-4 °C
[ Molecular Formula ]:
C3H6Cl2O
[ Molecular Weight ]:
128.985
[ Flash Point ]:
85.6±0.0 °C
[ Exact Mass ]:
127.979568
[ PSA ]:
20.23000
[ LogP ]:
0.66
[ Vapour Pressure ]:
0.4±0.7 mmHg at 25°C
[ Index of Refraction ]:
1.462
[ Water Solubility ]:
soluble. >=10 g/100 mL at 23 ºC
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UB1400000
- CHEMICAL NAME :
- 2-Propanol, 1,3-dichloro-
- CAS REGISTRY NUMBER :
- 96-23-1
- BEILSTEIN REFERENCE NO. :
- 1732063
- LAST UPDATED :
- 199801
- DATA ITEMS CITED :
- 18
- MOLECULAR FORMULA :
- C3-H6-Cl2-O
- MOLECULAR WEIGHT :
- 128.99
- WISWESSER LINE NOTATION :
- G1YQ1G
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Open irritation test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 110 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 125 ppm/4H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 25 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 800 uL/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4550 mg/kg/2Y-C
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - tumors
MUTATION DATA
- TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Rodent - hamster Lung
- DOSE/DURATION :
- 250 umol/L
- REFERENCE :
- ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 9,401,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-GERMANY;Carcinogen JAN 1993 OEL-RUSSIA:STEL 5 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5378 No. of Facilities: 3 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 200 (estimated) No. of Female Employees: 6 (estimated)
Safety Information
[ Symbol ]:
GHS06, GHS08
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H301-H312-H350
[ Precautionary Statements ]:
P201-P280-P301 + P310-P308 + P313
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
T:Toxic;
[ Risk Phrases ]:
R21;R25;R45
[ Safety Phrases ]:
S53-S45-S36/37-S16
[ RIDADR ]:
UN 2750 6.1/PG 2
[ WGK Germany ]:
3
[ RTECS ]:
UB1400000
[ Packaging Group ]:
II
[ Hazard Class ]:
6.1
[ HS Code ]:
29055910
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2905590090
[ Summary ]:
2905590090 other halogenated, sulphonated, nitrated or nitrosated derivatives of acyclic alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%
Articles
Food Chem. 166 , 301-8, (2014)
Sodium chloride has been shown to promote chlorination of glycerol during thermal processing. However, the detailed mechanism of this reaction is not well understood. Preliminary experiments have indi...
Appl. Environ. Microbiol. 81(8) , 2919-26, (2015)
Halohydrin dehalogenase from Agrobacterium radiobacter AD1 (HheC) shows great potential in producing valuable chiral epoxides and β-substituted alcohols. The wild-type (WT) enzyme displays a high R-en...
Bioorg. Med. Chem. 16 , 5720-32, (2008)
The risk of the presence of haloacetic acids in drinking water as chlorination by-products and the shortage of experimental mutagenicity data for most of them requires a research work. This paper desc...