Isoliquiritigenin

Suppliers

Names

[ CAS No. ]:
961-29-5

[ Name ]:
Isoliquiritigenin

[Synonym ]:
iso-Liquiritigenin
Isoliquiritigenin
QR CQ DV1U1R DQ &&E Form
ISL
(2E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one
gu17
2-Propen-1-one, 1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)-, (2E)-
MFCD00075907
(2E)-1-(2,4-Dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one
(E)-1-(2,4-Dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one
ISOLIQUIRTIGENIN
4,2',4'-TRIHYDROXYCHALCONE
Isqliquiritigenin
2',4',4-TRIHYDROXYCHALCONE
(E)-1-(2,4-Dihydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one
2',4,4'-Trihydroxychalcone

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
504.0±42.0 °C at 760 mmHg

[ Melting Point ]:
206-210°C

[ Molecular Formula ]:
C₁₅H₁₂O₄

[ Molecular Weight ]:
256.253

[ Flash Point ]:
272.7±24.4 °C

[ Exact Mass ]:
256.073547

[ PSA ]:
77.76000

[ LogP ]:
3.11

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.715

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
H2O: <0.1 mg/mL

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FL7080000

CHEMICAL NAME :: Chalcone, 2',4,4'-trihydroxy-

CAS REGISTRY NUMBER :: 961-29-5

LAST UPDATED :: 199606

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C15-H12-O4

MOLECULAR WEIGHT :: 256.27

WISWESSER LINE NOTATION :: QR CQ DV1U1R DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 100 ug/plate

REFERENCE :: ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 3,401,1981

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
FL7080000

[ HS Code ]:
2914501900

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Liquiritigenin
6-hydroxy-2-[hydroxy-(4-hydroxyphenyl)methyl]-1-benzofuran-3-one
2,4-Dihydroxybenzoic acid
3,7,4'-trihydroxyflavone
trans-3,4',7-trihydroxyflavanone
(2,4-dihydroxy-phenyl)-[4-(4-hydroxy-phenyl)-[1,2]dioxetan-3-yl]-methanone
chalaurenol
2,4-Dihydroxyacetophenone
5-hydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one
4-hydroxybenzaldehyde

Customs

[ HS Code ]: 2914501900

[ Summary ]:
2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Articles

Isoliquiritigenin attenuates oxidative hepatic damage induced by carbon tetrachloride with or without buthionine sulfoximine.

Chem. Biol. Interact. 225 , 13-20, (2015)

Glycyrrhizae radix (G. radix) has been demonstrated to have hepatoprotective properties. This study determined the therapeutic effects of isoliquiritigenin (isoLQ) in G. radix, against liver injury in...

Effects of phytochemicals on in vitro anti-inflammatory activity of Bifidobacterium adolescentis.

Biosci. Biotechnol. Biochem. 79 , 799-807, (2015)

Probiotics have been shown to improve the condition of not only the human gastrointestinal tract but also the entire body. We found that quercetin enhances the anti-inflammatory activity of Bifidobact...

Flavonoids and Auxin Transport Inhibitors Rescue Symbiotic Nodulation in the Medicago truncatula Cytokinin Perception Mutant cre1.

Plant Cell 27 , 2210-26, (2015)

Initiation of symbiotic nodules in legumes requires cytokinin signaling, but its mechanism of action is largely unknown. Here, we tested whether the failure to initiate nodules in the Medicago truncat...