Ethyl 2,6-dichloro-5-fluoro-pyridine-3-acetoacetate

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Names

[ Name ]:
Ethyl 2,6-dichloro-5-fluoro-pyridine-3-acetoacetate

[Synonym ]:
3-Pyridinebutanoic acid, 2,6-dichloro-5-fluoro-β-oxo-, ethyl ester
MFCD00799535
Ethyl 4-(2,6-dichloro-5-fluoro-3-pyridinyl)-3-oxobutanoate
Ethyl 4-(2,6-dichloro-5-fluoropyridin-3-yl)-3-oxobutanoate
ethyl 3-(2,6-dichloro-5-fluoropyridin-3-yl)-3-oxopropanoate

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
363.4±37.0 °C at 760 mmHg

[ Melting Point ]:
68-72 °C(lit.)

[ Molecular Formula ]:
C₁₁H₁₀Cl₂FNO₃

[ Molecular Weight ]:
294.106

[ Flash Point ]:
173.6±26.5 °C

[ Exact Mass ]:
293.002167

[ PSA ]:
56.26000

[ LogP ]:
2.41

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.521

[ Storage condition ]:
-20°C Freezer

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

diethyl (2,6-dichloro-5-fluoro-pyridine-3-carbonyl)-malonate
Potassium monoethyl malonate
2,6-Dichloro-5-fluoronicotinonitrile
Monoethyl malonic acid
2,6-dichloro-5-fluoronicotinoyl chloride
2,6-Dihydroxy-5-fluoro-3-cyanopyridine
2,6-Dichloro-5-fluoronicotinic acid
ethyl 2-hydrazono-2-(2,6-dichloro-5-fluoronicotinoyl)acetate
ethyl 2-diazo-2-(2,6-dichloro-5-fluoronicotinoyl)acetate
ethyl 2,6-dichloro-5-fluoropyridine-3-carboxylate

DownStream

ethyl 6-fluoro-1-(4-fluorophenyl)-7-(4-methylpiperazin-1-yl)-4-oxo-1,8-naphthyridine-3-carboxylate
Tosufloxacin pharmaceutical intermediate
Ethyl 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate
ethyl 1-(2,4-difluorophenyl)-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,8-naphthyridine-3-carboxylate
ethyl 6-fluoro-1-(4-fluorophenyl)-7-(3-methylpiperazin-1-yl)-4-oxo-1,8-naphthyridine-3-carboxylate
ethyl 1-(2,4-difluorophenyl)-6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxo-1,8-naphthyridine-3-carboxylate
ethyl 7-chloro-6-fluoro-1-(4-fluorophenyl)-4-oxo-1,8-naphthyridine-3-carboxylate
Ethyl-2-(2,6-dichlor-5-fluorpyridin-3-carbonyl)-3-(2,4-difluorphenylamino)-acrylat
ethyl 6-fluoro-1-(4-fluorophenyl)-4-oxo-7-piperazin-1-yl-1,8-naphthyridine-3-carboxylate
ethyl 1-(2,4-difluorophenyl)-6-fluoro-4-oxo-7-piperazin-1-yl-1,8-naphthyridine-3-carboxylate

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

Tert-butyl 6-(trifluoromethyl)morpholine-3-carboxylate
(9H-fluoren-9-yl)methyl N-(prop-2-en-1-yl)-N-propylcarbamate
(9H-fluoren-9-yl)methyl N-(1-cyclobutylprop-2-en-1-yl)carbamate
3-Amino-3-[1-(methylsulfanyl)cyclopropyl]propanamide
Benzyl 3-cyanoazepane-1-carboxylate
L-Alanine, N-[2-(cyclopentylamino)-1-methyl-2-oxoethyl]-
[(4-Methyloxan-4-yl)methyl]hydrazine
Cinchonan, 10,11-dihydro-6a(2)-methoxy-9-phenoxy-, (8I+/-,9R)-
Tyrosine, 3-[(4-chloro-2-methylphenoxy)methyl]-O-methyl-
4-(3-bromo-2,4-dimethylphenyl)-1H-imidazole

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