Oxychlorpromazine
Suppliers
Names
[ CAS No. ]:
969-99-3
[ Name ]:
Oxychlorpromazine
[Synonym ]:
Chlorpromazine sulphoxide
Opromazine
Chlorpromazine-S-oxyd
Oxychlorpromazine
Chloropromazine sulfoxide
Opromazin
Transedon
Chlorpromazine sulfoxide
Chlorpromazine-S-oxide
Secotil
Chemical & Physical Properties
[ Density]:
1.35g/cm3
[ Boiling Point ]:
502.6ºC at 760 mmHg
[ Melting Point ]:
115°
[ Molecular Formula ]:
C17H19ClN2OS
[ Molecular Weight ]:
334.86400
[ Flash Point ]:
257.8ºC
[ Exact Mass ]:
334.09100
[ PSA ]:
42.76000
[ LogP ]:
4.84060
[ Index of Refraction ]:
1.687
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- SO2275000
- CHEMICAL NAME :
- Phenothiazine, 2-chloro-10-(3-(dimethylamino)propyl)-, sulfoxide
- CAS REGISTRY NUMBER :
- 969-99-3
- BEILSTEIN REFERENCE NO. :
- 0307255
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C17-H19-Cl-N2-O-S
- MOLECULAR WEIGHT :
- 334.89
- WISWESSER LINE NOTATION :
- T C666 BN ISJ B3N1&1 EG IO
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 163 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 118,328,1956
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 102 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NAIZAM Nara Igaku Zasshi. Journal of the Nara Medical Association. (Nara Igakkai, c/o Narakenritsu Ika Daigaku, Shijo-cho, Kashihara, Nara-ken, Japan) V.1- 1950- Volume(issue)/page/year: 8,50,1957
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 90 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 53,71S,1957
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
Se Pu 30(9) , 938-42, (2012)
Based on the phenomenon that each of chlorpromazine (CPZ), promethazine (PMZ), chlorpromazine sulfoxide (CPZSO) and promethazine sulfoxide (PMZSO) could enhance the electrochemiluminescence (ECL) inte...
Photochem. Photobiol. 44(1) , 5-10, (1986)
Biochemistry 26(25) , 8133-7, (1987)
The effects of phenothiazines (chlorpromazine, chlorpromazine sulfoxide, and trifluoperazine) and antimitotic drugs (colchicine and vinblastine) on the erythrocyte membrane have been investigated. Chl...