Oxychlorpromazine

Modify Date: 2024-01-02 11:47:21

Oxychlorpromazine Structure
Oxychlorpromazine structure
Common Name Oxychlorpromazine
CAS Number 969-99-3 Molecular Weight 334.86400
Density 1.35g/cm3 Boiling Point 502.6ºC at 760 mmHg
Molecular Formula C17H19ClN2OS Melting Point 115°
MSDS N/A Flash Point 257.8ºC

 Names

Name 3-(2-chloro-5-oxophenothiazin-10-yl)-N,N-dimethylpropan-1-amine
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.35g/cm3
Boiling Point 502.6ºC at 760 mmHg
Melting Point 115°
Molecular Formula C17H19ClN2OS
Molecular Weight 334.86400
Flash Point 257.8ºC
Exact Mass 334.09100
PSA 42.76000
LogP 4.84060
Index of Refraction 1.687

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SO2275000
CHEMICAL NAME :
Phenothiazine, 2-chloro-10-(3-(dimethylamino)propyl)-, sulfoxide
CAS REGISTRY NUMBER :
969-99-3
BEILSTEIN REFERENCE NO. :
0307255
LAST UPDATED :
199612
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C17-H19-Cl-N2-O-S
MOLECULAR WEIGHT :
334.89
WISWESSER LINE NOTATION :
T C666 BN ISJ B3N1&1 EG IO

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
163 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 118,328,1956
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
102 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NAIZAM Nara Igaku Zasshi. Journal of the Nara Medical Association. (Nara Igakkai, c/o Narakenritsu Ika Daigaku, Shijo-cho, Kashihara, Nara-ken, Japan) V.1- 1950- Volume(issue)/page/year: 8,50,1957
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
90 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 53,71S,1957

 Synthetic Route

~1%

Detail
Literature: Slavik, Roger; Peters, Jens-Uwe; Giger, Rudolf; Buerkler, Markus; Bald, Eric Tetrahedron Letters, 2011 , vol. 52, # 7 p. 749 - 752

~91%

Oxychlorpromazine Structure

Oxychlorpromazine

CAS#:969-99-3

Literature: Owens; Juenge; Poklis Journal of Pharmaceutical Sciences, 1989 , vol. 78, # 4 p. 334 - 336

~83%

Oxychlorpromazine Structure

Oxychlorpromazine

CAS#:969-99-3

Literature: Stalder, Romain; Roth, Gregory P. ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 11 p. 1119 - 1123

~99%

Oxychlorpromazine Structure

Oxychlorpromazine

CAS#:969-99-3

Literature: Bosch, Eric; Kochi, Jay K. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1995 , # 8 p. 1057 - 1064

~%

Oxychlorpromazine Structure

Oxychlorpromazine

CAS#:969-99-3

Literature: Kano; Fujimoto Pharmaceutical Bulletin, 1957 , vol. 5, p. 393,396

~%

Oxychlorpromazine Structure

Oxychlorpromazine

CAS#:969-99-3

Literature: Wisniewska, Joanna; Rzesnicki, Pawel; Topolski, Adrian Transition Metal Chemistry, 2011 , vol. 36, # 7 p. 767 - 774

 Articles25

More Articles
[Simultaneous determination of chlorpromazine and promethazine and their main metabolites by capillary electrophoresis with electrochemiluminescence].

Se Pu 30(9) , 938-42, (2012)

Based on the phenomenon that each of chlorpromazine (CPZ), promethazine (PMZ), chlorpromazine sulfoxide (CPZSO) and promethazine sulfoxide (PMZSO) could enhance the electrochemiluminescence (ECL) inte...

Free radical production by chlorpromazine sulfoxide, an ESR spin-trapping and flash photolysis study.

Photochem. Photobiol. 44(1) , 5-10, (1986)

Involvement of erythrocyte skeletal proteins in the modulation of membrane fluidity by phenothiazines.

Biochemistry 26(25) , 8133-7, (1987)

The effects of phenothiazines (chlorpromazine, chlorpromazine sulfoxide, and trifluoperazine) and antimitotic drugs (colchicine and vinblastine) on the erythrocyte membrane have been investigated. Chl...

 Synonyms

Chlorpromazine sulphoxide
Opromazine
Chlorpromazine-S-oxyd
Oxychlorpromazine
Chloropromazine sulfoxide
Opromazin
Transedon
Chlorpromazine sulfoxide
Chlorpromazine-S-oxide
Secotil