Bithionol

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Names

[ CAS No. ]:
97-18-7

[ Name ]:
Bithionol

[Synonym ]:
Phenol, 2,2'-thiobis(4,6-dichloro)-
Phenol, 2,2'-thiobis[4,6-dichloro-
Bitin
2-Hydroxy-3,5-dichlorophenyl sulfide
Bithionolate
2,2'-Thiobis[4,6-dichlorophenol]
2,2-DIMETHYL-7-ETHOXY-6-METHOXY-4-CHROMANONE
MFCD00055727
2,2'-Sulfanediylbis(4,6-dichlorophenol)
Bidiphen
2,2'-Thiobis- (4,6-dichlorophenol)
2,2’-thiobis[4,6-dichlorophenol]
Bithionol sulfide
Bithin
EINECS 202-565-0
2,2'-Thio-bis(4,6-dichlorophenol)
2,2'-Thiobis(4,6-dichlorophenol)
Bithionol
2,2'-Sulfanediylbis(4,6-dichlorphenol)
2,2’-sulfanediylbis(4,6-dichlorophenol)
Bitionol
Bis(2-hydroxy-3,5-dichlorophenyl)sulfide
2-Hydroxy-3,5-dichlorophenyl sulphide
2,4-dichloro-6-(3,5-dichloro-2-hydroxyphenyl)sulfanylphenol
bis (2-hydroxy-3,5-dichlorophenyl)-sulphide
bis(3,5-dichloro-2-hydroxy phenyl)-sulfide
Phenol, 2,2'-thiobis 4,6-dichloro-
2,2’-thiobis(4,6-dichlorophenol)
Lorothidol
Actamer

Chemical & Physical Properties

[ Density]:
1.8±0.1 g/cm3

[ Boiling Point ]:
444.7±45.0 °C at 760 mmHg

[ Melting Point ]:
188°C

[ Molecular Formula ]:
C12H6Cl4O2S

[ Molecular Weight ]:
356.052

[ Flash Point ]:
222.8±28.7 °C

[ Exact Mass ]:
353.884247

[ PSA ]:
65.76000

[ LogP ]:
5.51

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.741

[ Storage condition ]:
0-6°C

[ Stability ]:
Stable. Incompatible with strong oxidizing agents.

[ Water Solubility ]:
<0.1 g/100 mL at 23 ºC

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SN0525000
CHEMICAL NAME :
Phenol, 2,2'-thiobis(4,6-dichloro-
CAS REGISTRY NUMBER :
97-18-7
BEILSTEIN REFERENCE NO. :
2003535
LAST UPDATED :
199710
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C12-H6-Cl4-O2-S
MOLECULAR WEIGHT :
356.04
WISWESSER LINE NOTATION :
QR BG DG FSR BQ CG EG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
7 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
760 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,612,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
18 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#01763 ** TUMORIGENIC DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
12 gm/kg/78W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Blood - tumors
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB223-159

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Precautionary Statements ]:
P301 + P312 + P330

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
S28-S36/37-S45-S36

[ RIDADR ]:
UN 2811 6.1/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
SN0525000

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1(a)

[ HS Code ]:
2930909090

Synthetic Route

Precursor & DownStream

Precursor

  • 2,4-Dichlorophenol
  • Carbon disulphide
  • Aluminium chloride
  • Carbon tetrachloride

DownStream

  • Bithionol (sulfoxide)
  • 2,4-dichloro-6-(3,5-dichloro-2-hydroxyphenyl)sulfonylphenol

Customs

[ HS Code ]: 2930909090

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

An improved thyroid hormone reporter assay to determine the thyroid hormone-like activity of amiodarone, bithionol, closantel and rafoxanide.

Toxicol. Lett. 208(1) , 30-5, (2012)

A number of environmental chemicals have been reported to exhibit thyroid hormone-like activity. Since thyroid hormones play a crucial role in development, it is important to identify chemicals in the...

Determination of bithionol, bromophen, nitroxynil, oxyclozanide, and tribromsalan in milk with liquid chromatography coupled with tandem mass spectrometry.

J. AOAC Int. 93(4) , 1340-6, (2010)

LC/MS/MS was developed to determine the residues of bithionol (BTN), bromofen (BMF), nitroxynil (NTX), oxyclozanide (OCZ), and tribromsalan (TBS) in milk. Samples were extracted with ethyl acetate and...

Novel therapeutic strategy for neurodegeneration by blocking Aβ seeding mediated aggregation in models of Alzheimer's disease.

Neurobiol. Dis. 74 , 144-57, (2015)

Aβ accumulation plays a central role in the pathogenesis of Alzheimer's disease (AD). Recent studies suggest that the process of Aβ nucleated polymerization is essential for Aβ fibril formation, patho...


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Related Compounds

  • Bithionoloxide
  • Bithionol sulfone
  • Natrii bithionolas
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • Tert-butyl 8-bromo-1,2,3,5-tetrahydro-4,1-benzoxazepine-1-carboxylate
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • 4-[(3-bromo-1-methyl-1H-pyrazol-5-yl)methyl]-4-methoxypiperidine
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine