Bithionol
Bithionol structure
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Common Name | Bithionol | ||
|---|---|---|---|---|
| CAS Number | 97-18-7 | Molecular Weight | 356.052 | |
| Density | 1.8±0.1 g/cm3 | Boiling Point | 444.7±45.0 °C at 760 mmHg | |
| Molecular Formula | C12H6Cl4O2S | Melting Point | 188°C | |
| MSDS | Chinese USA | Flash Point | 222.8±28.7 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of BithionolBithionol is a clinically approved anti-parasitic drug; has been shown to inhibit solid tumor growth in several preclinical cancer models.IC50 value:Target: anticaner agentBithionol caused dose dependent cytotoxicity against all ovarian cancer cell lines tested with IC50 values ranging from 19 μM - 60 μM. BT treatment resulted in cell cycle arrest at G1/M phase and increased ROS generation [1]. Both bithionol and bithionol sulphoxide demonstrated in vitro toxicity to Neoparamoeba spp. at all concentrations examined (0.1 to 10 mg l(-1) over 72 h), with a comparable toxicity to freshwater observed for both chemicals at concentrations > 5 mg l(-1) following a 72 h treatment [2]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | bithionol |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Bithionol is a clinically approved anti-parasitic drug; has been shown to inhibit solid tumor growth in several preclinical cancer models.IC50 value:Target: anticaner agentBithionol caused dose dependent cytotoxicity against all ovarian cancer cell lines tested with IC50 values ranging from 19 μM - 60 μM. BT treatment resulted in cell cycle arrest at G1/M phase and increased ROS generation [1]. Both bithionol and bithionol sulphoxide demonstrated in vitro toxicity to Neoparamoeba spp. at all concentrations examined (0.1 to 10 mg l(-1) over 72 h), with a comparable toxicity to freshwater observed for both chemicals at concentrations > 5 mg l(-1) following a 72 h treatment [2]. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.8±0.1 g/cm3 |
|---|---|
| Boiling Point | 444.7±45.0 °C at 760 mmHg |
| Melting Point | 188°C |
| Molecular Formula | C12H6Cl4O2S |
| Molecular Weight | 356.052 |
| Flash Point | 222.8±28.7 °C |
| Exact Mass | 353.884247 |
| PSA | 65.76000 |
| LogP | 5.51 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.741 |
| InChIKey | JFIOVJDNOJYLKP-UHFFFAOYSA-N |
| SMILES | Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O |
| Storage condition | 0-6°C |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Water Solubility | <0.1 g/100 mL at 23 ºC |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Precautionary Statements | P301 + P312 + P330 |
| Personal Protective Equipment | Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | R20/21/22 |
| Safety Phrases | S28-S36/37-S45-S36 |
| RIDADR | UN 2811 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | SN0525000 |
| Packaging Group | II |
| Hazard Class | 6.1(a) |
| HS Code | 2930909090 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
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Bithionol CAS#:97-18-7 |
| Literature: DE583055 , ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 20, p. 426 |
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Bithionol CAS#:97-18-7 |
| Literature: DE583055 , ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 20, p. 426 |
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Bithionol CAS#:97-18-7 |
| Literature: DE583055 , ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 20, p. 426 |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 4 | |
|---|---|
| DownStream 2 | |
CAS#:844-26-8
CAS#:4568-36-9This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2930909090 |
|---|---|
| Summary | 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
This table lists relevant public references with title, journal and publication metadata for this compound.
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An improved thyroid hormone reporter assay to determine the thyroid hormone-like activity of amiodarone, bithionol, closantel and rafoxanide.
Toxicol. Lett. 208(1) , 30-5, (2012) A number of environmental chemicals have been reported to exhibit thyroid hormone-like activity. Since thyroid hormones play a crucial role in development, it is important to identify chemicals in the... |
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Determination of bithionol, bromophen, nitroxynil, oxyclozanide, and tribromsalan in milk with liquid chromatography coupled with tandem mass spectrometry.
J. AOAC Int. 93(4) , 1340-6, (2010) LC/MS/MS was developed to determine the residues of bithionol (BTN), bromofen (BMF), nitroxynil (NTX), oxyclozanide (OCZ), and tribromsalan (TBS) in milk. Samples were extracted with ethyl acetate and... |
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Novel therapeutic strategy for neurodegeneration by blocking Aβ seeding mediated aggregation in models of Alzheimer's disease.
Neurobiol. Dis. 74 , 144-57, (2015) Aβ accumulation plays a central role in the pathogenesis of Alzheimer's disease (AD). Recent studies suggest that the process of Aβ nucleated polymerization is essential for Aβ fibril formation, patho... |
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| Bitin |
| 2-Hydroxy-3,5-dichlorophenyl sulfide |
| Bithionolate |
| 2,2'-Thiobis[4,6-dichlorophenol] |
| 2,2-DIMETHYL-7-ETHOXY-6-METHOXY-4-CHROMANONE |
| MFCD00055727 |
| 2,2'-Sulfanediylbis(4,6-dichlorophenol) |
| Bidiphen |
| 2,2'-Thiobis- (4,6-dichlorophenol) |
| 2,2’-thiobis[4,6-dichlorophenol] |
| Bithionol sulfide |
| Bithin |
| EINECS 202-565-0 |
| 2,2'-Thio-bis(4,6-dichlorophenol) |
| 2,2'-Thiobis(4,6-dichlorophenol) |
| Bithionol |
| 2,2'-Sulfanediylbis(4,6-dichlorphenol) |
| 2,2’-sulfanediylbis(4,6-dichlorophenol) |
| Bitionol |
| Bis(2-hydroxy-3,5-dichlorophenyl)sulfide |
| 2-Hydroxy-3,5-dichlorophenyl sulphide |
| 2,4-dichloro-6-(3,5-dichloro-2-hydroxyphenyl)sulfanylphenol |
| bis (2-hydroxy-3,5-dichlorophenyl)-sulphide |
| bis(3,5-dichloro-2-hydroxy phenyl)-sulfide |
| 2,2’-thiobis(4,6-dichlorophenol) |
| Lorothidol |
| Actamer |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the CAS number of bithionol? |
| A: CAS number of bithionol is 97-18-7. |
| Q: What is the melting point of bithionol? |
| A: Melting point of bithionol is 188°C. |
| Q: What is the polar surface area (PSA) of bithionol? |
| A: Polar surface area (PSA) of bithionol is 65.76000. |
| Q: What are the upstream materials of bithionol? |
| A: Related upstream materials(CAS) of bithionol: 120-83-2;75-15-0;7446-70-0;56-23-5. |
| Q: What is the InChIKey of bithionol? |
| A: InChIKey of bithionol is JFIOVJDNOJYLKP-UHFFFAOYSA-N. |
| Q: What are the storage conditions for bithionol? |
| A: Storage conditions for bithionol: 0-6°C. |
| Q: What is the safety information for bithionol? |
| A: Safety information for bithionol: S28-S36/37-S45-S36. |
| Q: What are the downstream products of bithionol? |
| A: Related downstream products(CAS) of bithionol: 844-26-8;4568-36-9. |
| Q: What is the molecular weight of bithionol? |
| A: Molecular weight of bithionol is 356.052. |
| Q: What is the molecular formula of bithionol? |
| A: Molecular formula of bithionol is C12H6Cl4O2S. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |