5-Nitrosalicylaldehyde

Names

[ CAS No. ]:
97-51-8

[ Name ]:
5-Nitrosalicylaldehyde

[Synonym ]:
WNR DQ CVH
MFCD00007337
5-Nitrosalicylaldehyde
2-Formyl-4-nitrophenol
2-Hydroxy-5-nitrobenzaldehyde
Benzaldehyde, 2-hydroxy-5-nitro-
EINECS 202-587-0

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
300.2±32.0 °C at 760 mmHg

[ Melting Point ]:
125-128 °C(lit.)

[ Molecular Formula ]:
C₇H₅NO₄

[ Molecular Weight ]:
167.119

[ Flash Point ]:
137.3±13.6 °C

[ Exact Mass ]:
167.021851

[ PSA ]:
83.12000

[ LogP ]:
2.08

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.667

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CU6675000

CHEMICAL NAME :: Benzaldehyde, 2-hydroxy-5-nitro-

CAS REGISTRY NUMBER :: 97-51-8

LAST UPDATED :: 199710

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C7-H5-N-O4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 799 mg/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea Skin and Appendages - hair

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0533615

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 672 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - muscle weakness Skin and Appendages - hair

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0533628

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22;R36/37/38

[ Safety Phrases ]:
S26-S36-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
CU6675000

[ HS Code ]:
2913000090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Salicylaldehyde
4-Nitrophenol
Aminoform
2-(1-hydroxy-3-phenylprop-2-yn-1-yl)-4-nitrophenol
2-Methylbenzyl Alcohol
Spiro[2H-1-benzopyran-2,2'-[2H]indole],1',3'-dihydro-1',3',3'-trimethyl-6-nitro-
1-(ACRYLOYLOXY)-2,5-PYRROLIDINEDIONE
4-nitro-6-[(2-phenylhydrazinyl)methylidene]cyclohexa-2,4-dien-1-one
Methanediol,1-[2-(acetyloxy)-5-nitrophenyl]-, 1,1-diacetate
Ethanol

DownStream

2-naphthalen-1-yl-3,6-dinitro-2H-chromene
BENZOFURAN-5-AMINE
5-Nitro-1,2-benzisoxazole
5-Nitrobenzooxazol-2-amine
3-bromo-2-hydroxy-5-nitrobenzoic acid
methyl 6-nitro-2-oxo-2H-chromene-3-carboxylate
1-(ACRYLOYLOXY)-2,5-PYRROLIDINEDIONE
(2-hydroxy-5-nitrophenyl)-phenylmethanone
6-nitro-3-(4-nitrophenyl)chromen-2-one
5-Nitrobenzofuran

Customs

[ HS Code ]: 2913000090

[ Summary ]:
HS: 2913000090 halogenated, sulphonated, nitrated or nitrosated derivatives of products of heading 2912 Educational tariff:17.0% Tax rebate rate:9.0% Regulatory conditions:none Most favored nation tariff:5.5% General tariff:30.0%

Articles

Spiropyran-Decorated SiO₂-Pt Janus Micromotor: Preparation and Light-Induced Dynamic Self-Assembly and Disassembly.

ACS Appl. Mater. Interfaces 7 , 24585-91, (2015)

The controlled self-assembly of self-propelled Janus micromotors may give the micromotors some potential applications in many fields. In this work, we design a kind of SiO2-Pt Janus catalytic micromot...

Chlorogenic acid and hydroxynitrobenzaldehyde: new inhibitors of hepatic glucose 6-phosphatase.

Arch. Biochem. Biophys. 339(2) , 315-22, (1997)

We have studied the interactions of chlorogenic acid (CHL) and 2-hydroxy-5-nitrobenzaldehyde (HNB) with the components of the rat hepatic glucose 6-phosphatase (Glc-6-Pase) system. CHL and HNB are com...

Localization of cathepsin B activity in fibroblasts and chondrocytes by continuous monitoring of the formation of a final fluorescent reaction product using 5-nitrosalicylaldehyde.

Histochem. J. 19(9) , 483-7, (1987)

The histochemical fluorescence method using 5-nitrosalicylaldehyde for the demonstration of cathepsin B activity has been used. Precipitation of the fluorescent final reaction product was analysed con...