Tetramethylthiuram sulfide
Suppliers
Names
[ CAS No. ]:
97-74-5
[ Name ]:
Tetramethylthiuram sulfide
[Synonym ]:
Tetramethylthiuram sulfide
Trithiodicarbonic diamide, N,N,N',N'-tetramethyl-
Sulfide, bis[(dimethylamino)thioxomethyl]
EINECS 202-605-7
N,N,N',N'-Tetramethyldicarbonotrithioic diamide
Bis(dimethylthiocarbamyl) sulfide
MFCD00014870
Bis(dimethylthiocarbamyl) monosulfide
TMTM
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Boiling Point ]:
260.9±23.0 °C at 760 mmHg
[ Melting Point ]:
107-111 °C(lit.)
[ Molecular Formula ]:
C6H12N2S3
[ Molecular Weight ]:
208.368
[ Flash Point ]:
111.6±22.6 °C
[ Exact Mass ]:
208.016251
[ PSA ]:
95.96000
[ LogP ]:
0.87
[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C
[ Index of Refraction ]:
1.641
[ Water Solubility ]:
insoluble
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- WQ1750000
- CHEMICAL NAME :
- Sulfide, bis(dimethylthiocarbamoyl)
- CAS REGISTRY NUMBER :
- 97-74-5
- BEILSTEIN REFERENCE NO. :
- 1775650
- LAST UPDATED :
- 199806
- DATA ITEMS CITED :
- 21
- MOLECULAR FORMULA :
- C6-H12-N2-S3
- MOLECULAR WEIGHT :
- 208.38
- WISWESSER LINE NOTATION :
- 1N1&YUS&SYUS&N1&1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 450 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 383 mg/kg
- TOXIC EFFECTS :
- Behavioral - changes in motor activity (specific assay) Nutritional and Gross Metabolic - body temperature decrease
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 818 mg/kg
- TOXIC EFFECTS :
- Liver - other changes Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Blood - changes in cell count (unspecified)
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 300 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 850 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 20 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - species unspecified
- DOSE/DURATION :
- 10 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 520 mg/kg/4W-I
- TOXIC EFFECTS :
- Liver - changes in liver weight Blood - pigmented or nucleated red blood cells Blood - changes in erythrocyte (RBC) count
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Blood - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 900 mg/kg
- SEX/DURATION :
- female 6-14 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
- TYPE OF TEST :
- Micronucleus test
MUTATION DATA
- TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Rodent - hamster Ovary
- DOSE/DURATION :
- 100 nmol/L
- REFERENCE :
- SWEHDO Scandinavian Journal of Work, Environment and Health. (Haartmaninkatu 1, SF-00290 Helsinki, 29, Finland) V.1- 1975- Volume(issue)/page/year: 9(Suppl 2),27,1983 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80220 No. of Facilities: 376 (estimated) No. of Industries: 7 No. of Occupations: 23 No. of Employees: 6032 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80220 No. of Facilities: 803 (estimated) No. of Industries: 18 No. of Occupations: 31 No. of Employees: 40683 (estimated) No. of Female Employees: 5320 (estimated)
Safety Information
[ Symbol ]:
GHS07, GHS09
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302-H317-H411
[ Precautionary Statements ]:
P273-P280
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves
[ Hazard Codes ]:
Xn:Harmful
[ Risk Phrases ]:
R22;R43;R51/53
[ Safety Phrases ]:
S24-S26-S37-S61
[ RIDADR ]:
UN 3077 9/PG 3
[ WGK Germany ]:
3
[ RTECS ]:
WQ1750000
[ Packaging Group ]:
III
[ Hazard Class ]:
9
[ HS Code ]:
3812100000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 3812100000
Articles
Mater. Sci. Eng. C. Mater. Biol. Appl. 58 , 396-408, (2015)
Antimony(III) halide complexes of the formulae {[SbBr(Me2DTC)2]n} (1), {[SbI(Me2DTC)2]n} (2) and {[(Me2DTC)2Sb(μ2-I)Sb(Me2DTC)2](+).I3(-)} (3) (Me2DTC = dimethyldithiocarbomate) were synthesized from ...
Contact Dermatitis 65(4) , 242-3, (2011)
Chem. Biol. Interact. 49(3) , 329-40, (1984)
In recent years data have accumulated regarding genotoxic properties of dithiocarbamic acid derivatives. The results from the present work indicate that the mutagenicity of these compounds depends on ...