Tetramethylthiuram sulfide

Modify Date: 2026-06-30 20:09:35

Tetramethylthiuram sulfide structure	Common Name	Tetramethylthiuram sulfide
	CAS Number	97-74-5	Molecular Weight	208.368
	Density	1.3±0.1 g/cm3	Boiling Point	260.9±23.0 °C at 760 mmHg
	Molecular Formula	C₆H₁₂N₂S₃	Melting Point	107-111 °C(lit.)
	MSDS	Chinese USA	Flash Point	111.6±22.6 °C
	Symbol	GHS07, GHS09	Signal Word	Warning

Use of Tetramethylthiuram sulfide

Tetramethylthiuram monosulfide (TMTM) is an active compound. Tetramethylthiuram monosulfide (TMTM) can be used for the research of rubber and various biochemical studies[1][2].

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	Bis(Dimethylthiocarbamoyl) Sulfide
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	Tetramethylthiuram monosulfide (TMTM) is an active compound. Tetramethylthiuram monosulfide (TMTM) can be used for the research of rubber and various biochemical studies[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Coleman, et al. Vibrational spectra of thiuram sulfides. Normal coordinate analysis of tetramethylthiuram mono-, di-, and tetrasulfides. Journal of Polymer Science, Polymer Physics Edition.Volume: 12.Issue: 5.Pages: 1001-13.Journal.1974. [2]. Yingtao Sun, et al. Synergistic Effect of Copper Sulfate and Tetramethylthiuram Monosulfide Induced Metal-Coordination Cross-Linking in Nitrile–Butadiene Rubber. 25 April 2021.

Description

Tetramethylthiuram monosulfide (TMTM) is an active compound. Tetramethylthiuram monosulfide (TMTM) can be used for the research of rubber and various biochemical studies[1][2].

Related Catalog

Research Areas >> Others

Signaling Pathways >> Others >> Others

References

[1]. Coleman, et al. Vibrational spectra of thiuram sulfides. Normal coordinate analysis of tetramethylthiuram mono-, di-, and tetrasulfides. Journal of Polymer Science, Polymer Physics Edition.Volume: 12.Issue: 5.Pages: 1001-13.Journal.1974.

[2]. Yingtao Sun, et al. Synergistic Effect of Copper Sulfate and Tetramethylthiuram Monosulfide Induced Metal-Coordination Cross-Linking in Nitrile–Butadiene Rubber. 25 April 2021.

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.3±0.1 g/cm3
Boiling Point	260.9±23.0 °C at 760 mmHg
Melting Point	107-111 °C(lit.)
Molecular Formula	C₆H₁₂N₂S₃
Molecular Weight	208.368
Flash Point	111.6±22.6 °C
Exact Mass	208.016251
PSA	95.96000
LogP	0.87
Vapour Pressure	0.0±0.5 mmHg at 25°C
Index of Refraction	1.641
InChIKey	REQPQFUJGGOFQL-UHFFFAOYSA-N
SMILES	CN(C)C(=S)SC(=S)N(C)C
Water Solubility	insoluble

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

Tetramethylthiuram sulfide MSDS(Chinese)

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WQ1750000

CHEMICAL NAME :: Sulfide, bis(dimethylthiocarbamoyl)

CAS REGISTRY NUMBER :: 97-74-5

BEILSTEIN REFERENCE NO. :: 1775650

LAST UPDATED :: 199806

DATA ITEMS CITED :: 21

MOLECULAR FORMULA :: C6-H12-N2-S3

MOLECULAR WEIGHT :: 208.38

WISWESSER LINE NOTATION :: 1N1&YUS&SYUS&N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 450 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 383 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Nutritional and Gross Metabolic - body temperature decrease

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 818 mg/kg

TOXIC EFFECTS :: Liver - other changes Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Blood - changes in cell count (unspecified)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 850 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 520 mg/kg/4W-I

TOXIC EFFECTS :: Liver - changes in liver weight Blood - pigmented or nucleated red blood cells Blood - changes in erythrocyte (RBC) count

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Blood - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 900 mg/kg

SEX/DURATION :: female 6-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: Micronucleus test

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 100 nmol/L

REFERENCE :: SWEHDO Scandinavian Journal of Work, Environment and Health. (Haartmaninkatu 1, SF-00290 Helsinki, 29, Finland) V.1- 1975- Volume(issue)/page/year: 9(Suppl 2),27,1983 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80220 No. of Facilities: 376 (estimated) No. of Industries: 7 No. of Occupations: 23 No. of Employees: 6032 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80220 No. of Facilities: 803 (estimated) No. of Industries: 18 No. of Occupations: 31 No. of Employees: 40683 (estimated) No. of Female Employees: 5320 (estimated)

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol	GHS07, GHS09
Signal Word	Warning
Hazard Statements	H302-H317-H411
Precautionary Statements	P273-P280
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xn:Harmful
Risk Phrases	R22;R43;R51/53
Safety Phrases	S24-S26-S37-S61
RIDADR	UN 3077 9/PG 3
WGK Germany	3
RTECS	WQ1750000
Packaging Group	III
Hazard Class	9
HS Code	3812100000

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 9
CAS#:16420-13-6 Dimethylcarbamo... CAS#:128-04-1 Sodium dimethyl... CAS#:75-15-0 Carbon disulphide CAS#:2782-91-4 Tetramethylthiourea
CAS#:124-40-3 Dimethylamine CAS#:137-26-8 Thiram CAS#:603-35-0 Triphenylphosphine CAS#:506-77-4 Cyanogen chloride
CAS#:143-33-9 Sodium cyanide
DownStream 9
CAS#:1115-06-6 Thioperoxydicar... CAS#:51207-31-9 2,3,7,8-Tetrach... CAS#:70648-26-9 1,2,3,4,7,8-hex... CAS#:542-18-7 Chlorocyclohexane
CAS#:4837-38-1 Cyclohexanesulf... CAS#:102-08-9 Thiocarbanilide CAS#:27849-33-8 2-hydroxyethyl ... CAS#:137-26-8 Thiram
CAS#:2782-91-4 Tetramethylthiourea

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code	3812100000

This table lists relevant public references with title, journal and publication metadata for this compound.

New antimony(III) halide complexes with dithiocarbamate ligands derived from thiuram degradation: The effect of the molecule's close contacts on in vitro cytotoxic activity.

Mater. Sci. Eng. C. Mater. Biol. Appl. 58 , 396-408, (2015)

Antimony(III) halide complexes of the formulae {[SbBr(Me2DTC)2]n} (1), {[SbI(Me2DTC)2]n} (2) and {[(Me2DTC)2Sb(μ2-I)Sb(Me2DTC)2](+).I3(-)} (3) (Me2DTC = dimethyldithiocarbomate) were synthesized from ...

Occupational allergic contact dermatitis of the ears caused by thiurams in a headset.

Contact Dermatitis 65(4) , 242-3, (2011)

Enzyme inhibition as a possible mechanism of the mutagenicity of dithiocarbamic acid derivatives in Salmonella typhimurium.

Chem. Biol. Interact. 49(3) , 329-40, (1984)

In recent years data have accumulated regarding genotoxic properties of dithiocarbamic acid derivatives. The results from the present work indicate that the mutagenicity of these compounds depends on ...

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Source: NCGC
External Id: SNCA-p-activity-luciferase

Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273

Name: p53 small molecule agonists, cell-based qHTS assay: qHTS cell viability counter scree...
Source: 824
Target: N/A
External Id: P53600

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: qHTS ce...
Source: 824
Target: N/A
External Id: P53MS958

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: Summary
Source: 824
External Id: P53MS482

Name: p53 small molecule agonists, cell-based qHTS assay
Source: 824
External Id: P53344

Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS233

Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes: qHTS ...
Source: 824
Target: N/A
External Id: P53MS837

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS898

Name: Primary qHTS to identify gynecologic anti-cancer compounds using libraries of approve...
Source: NCGC
Target: N/A
External Id: OBG420

Total 327, Current Page 1 of 33

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

Tetramethylthiuram sulfide

Sulfide, bis[(dimethylamino)thioxomethyl]

EINECS 202-605-7

N,N,N',N'-Tetramethyldicarbonotrithioic diamide

Bis(dimethylthiocarbamyl) sulfide

MFCD00014870

Bis(dimethylthiocarbamyl) monosulfide

TMTM

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the melting point of Bis(Dimethylthiocarbamoyl) Sulfide?

A: Melting point of Bis(Dimethylthiocarbamoyl) Sulfide is 107-111 °C(lit.).

Q: What is the CAS number of Bis(Dimethylthiocarbamoyl) Sulfide?

A: CAS number of Bis(Dimethylthiocarbamoyl) Sulfide is 97-74-5.

Q: What is the InChIKey of Bis(Dimethylthiocarbamoyl) Sulfide?

A: InChIKey of Bis(Dimethylthiocarbamoyl) Sulfide is REQPQFUJGGOFQL-UHFFFAOYSA-N.

Q: What English synonyms does Bis(Dimethylthiocarbamoyl) Sulfide have?

A: English synonyms of Bis(Dimethylthiocarbamoyl) Sulfide: Tetramethylthiuram sulfide, Sulfide, bis[(dimethylamino)thioxomethyl], EINECS 202-605-7, N,N,N',N'-Tetramethyldicarbonotrithioic diamide, Bis(dimethylthiocarbamyl) sulfide, MFCD00014870, Bis(dimethylthiocarbamyl) monosulfide, TMTM.

Q: What is the safety information for Bis(Dimethylthiocarbamoyl) Sulfide?

A: Safety information for Bis(Dimethylthiocarbamoyl) Sulfide: S24-S26-S37-S61.

Q: What is the SMILES notation of Bis(Dimethylthiocarbamoyl) Sulfide?

A: SMILES notation of Bis(Dimethylthiocarbamoyl) Sulfide is CN(C)C(=S)SC(=S)N(C)C.

Q: What is the polar surface area (PSA) of Bis(Dimethylthiocarbamoyl) Sulfide?

A: Polar surface area (PSA) of Bis(Dimethylthiocarbamoyl) Sulfide is 95.96000.

Q: What is the LogP of Bis(Dimethylthiocarbamoyl) Sulfide?

A: LogP of Bis(Dimethylthiocarbamoyl) Sulfide is 0.87.

Q: What are the upstream materials of Bis(Dimethylthiocarbamoyl) Sulfide?

A: Related upstream materials(CAS) of Bis(Dimethylthiocarbamoyl) Sulfide: 16420-13-6;128-04-1;75-15-0;2782-91-4;124-40-3;137-26-8;603-35-0;506-77-4;143-33-9.

Q: What are the downstream products of Bis(Dimethylthiocarbamoyl) Sulfide?

A: Related downstream products(CAS) of Bis(Dimethylthiocarbamoyl) Sulfide: 1115-06-6;51207-31-9;70648-26-9;542-18-7;4837-38-1;102-08-9;27849-33-8;137-26-8;2782-91-4.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

Dayang Chem (Hangzhou) Co., Ltd.

Henan Tianfu Chemical Co., Ltd.

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Tetramethylthiuram sulfide
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Bis(dimethylthiocarbamyl) sulfide
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Rubber Accelerator TMTM-Tetramethyl-thiuram Monosulfide
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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