Citrazinic acid

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Names

[ CAS No. ]:
99-11-6

[ Name ]:
Citrazinic acid

[Synonym ]:
2-hydroxy-6-oxo-1H-pyridine-4-carboxylic acid
4-Pyridinecarboxylic acid, 1,2-dihydro-6-hydroxy-2-oxo-
EINECS 202-731-2
6-Hydroxy-4-carboxy-2-pyridone
MFCD00006274
2,6-Dihydroxy-isonicotinic acid
1,2-Dihydro-6-hydroxy-2-oxo-4-pyridinecarboxylic Acid
6-hydroxy-2-oxo-1,2-dihydropyridine-4-carboxylic acid
Citrazinic acid
6-Hydroxy-2-oxo-1,2-dihydro-4-pyridinecarboxylic acid

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
630.3±55.0 °C at 760 mmHg

[ Melting Point ]:
>300 °C(lit.)

[ Molecular Formula ]:
C6H5NO4

[ Molecular Weight ]:
155.11

[ Flash Point ]:
335.0±31.5 °C

[ Exact Mass ]:
155.021851

[ PSA ]:
90.65000

[ LogP ]:
-1.50

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.686

[ Water Solubility ]:
practically insoluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NS1400000
CHEMICAL NAME :
Isonicotinic acid, 2,6-dihydroxy-
CAS REGISTRY NUMBER :
99-11-6
LAST UPDATED :
199710
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C6-H5-N-O4
MOLECULAR WEIGHT :
155.12
WISWESSER LINE NOTATION :
T6NJ BQ DVQ FQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>3200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650) Volume(issue)/page/year: 21MAY1971
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650) Volume(issue)/page/year: 21MAY1971
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
>20 mL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650) Volume(issue)/page/year: 21MAY1971 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - T1498 No. of Facilities: 43 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 255 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - T1498 No. of Facilities: 6 (estimated) No. of Industries: 2 No. of Occupations: 1 No. of Employees: 34 (estimated) No. of Female Employees: 3 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36-S36/37/39-S22

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
1

[ RTECS ]:
NS1400000

[ HS Code ]:
29333999

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Isonicotinic acid
  • 2-hydroxypropane-1,2,3-tricarboxamide
  • citric acid α,α'-diamide
  • citric acid α-amide
  • 2,6-Dichloroisonicotinic acid
  • Trimethyl citrate
  • Citric Acid
  • Urea

DownStream

  • 6,6''-BIS(BROMOMETHYL)-[2,2':6',2''-TERPYRIDINE]-4'-CARBOXYLIC ACID ETHYL ESTER
  • 2,6-Dimethylpyridine-4-carbonitrile
  • 4-Pyridinemethanol
  • tert-Butyl (2,6-dichloropyridin-4-yl)carbamate
  • propyl 4-(1,2-dihydroxybutan-2-yl)-6-methoxy-5-(phenylmethoxymethyl)pyridine-2-carboxylate
  • (S)-4-Ethyl-4,6-dihydroxy-3,10-dioxo-3,4,8,10-tetrahydro-1H-pyrano[3,4-f]indolizine-7-carboxylic acid tert-butyl ester
  • propyl (4S)-4-ethyl-3,4-dihydroxy-8-methoxy-1,3-dihydropyrano[3,4-c]pyridine-6-carboxylate
  • 7-Ethyl-10-hydroxycamptothecin
  • 4-Pyridinamine,2,6-dichloro-N-nitro-
  • Irinotecan

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

6,6'-Dibromo-4,4'-di(hexoxymethyl)-2,2'- bipyridine: a new solubilizing building block for macromolecular and supramolecular applications.

J. Org. Chem. 71(12) , 4696-9, (2006)

Although brominated bipyridines and terpyridines are highly desirable synthetic building blocks for both ligand design and macro- or supramolecular applications, few such synthetic precursors have bee...

Synthesis and antimicrobial activity of some new pyrimidinone and oxazinone derivatives fused with thiophene rings using 2-chloro-6-ethoxy-4-acetylpyridine as starting material.

Molecules 17(11) , 13642-55, (2012)

A series of pyridines, pyrimidinones, oxazinones and their derivatives were synthesized as antimicrobial agents using citrazinic acid (2,6-dihydroxyisonicotinic acid) as a starting material. α,β-Unsat...


More Articles

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  • citrazinic acid
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  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
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