Citrazinic acid

Modify Date: 2024-01-01 21:40:28

Citrazinic acid Structure
Citrazinic acid structure
Common Name Citrazinic acid
CAS Number 99-11-6 Molecular Weight 155.11
Density 1.7±0.1 g/cm3 Boiling Point 630.3±55.0 °C at 760 mmHg
Molecular Formula C6H5NO4 Melting Point >300 °C(lit.)
MSDS Chinese USA Flash Point 335.0±31.5 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of Citrazinic acid


Citrazinic acid is a weakly fluorescent compound whose optical properties are dependent on aggregation states and chemical environment. Citrazinic acid strongly tends to form dimers at high concentrations[1].

 Names

Name Citrazinic acid
Synonym More Synonyms

 Citrazinic acid Biological Activity

Description Citrazinic acid is a weakly fluorescent compound whose optical properties are dependent on aggregation states and chemical environment. Citrazinic acid strongly tends to form dimers at high concentrations[1].
Related Catalog
References

[1]. Stagi L, et al. Anomalous Optical Properties of Citrazinic Acid under Extreme pH Conditions. ACS Omega. 2020 May 5;5(19):10958-10964.  

 Chemical & Physical Properties

Density 1.7±0.1 g/cm3
Boiling Point 630.3±55.0 °C at 760 mmHg
Melting Point >300 °C(lit.)
Molecular Formula C6H5NO4
Molecular Weight 155.11
Flash Point 335.0±31.5 °C
Exact Mass 155.021851
PSA 90.65000
LogP -1.50
Vapour Pressure 0.0±1.9 mmHg at 25°C
Index of Refraction 1.686
Water Solubility practically insoluble

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NS1400000
CHEMICAL NAME :
Isonicotinic acid, 2,6-dihydroxy-
CAS REGISTRY NUMBER :
99-11-6
LAST UPDATED :
199710
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C6-H5-N-O4
MOLECULAR WEIGHT :
155.12
WISWESSER LINE NOTATION :
T6NJ BQ DVQ FQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>3200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650) Volume(issue)/page/year: 21MAY1971
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650) Volume(issue)/page/year: 21MAY1971
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
>20 mL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650) Volume(issue)/page/year: 21MAY1971 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - T1498 No. of Facilities: 43 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 255 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - T1498 No. of Facilities: 6 (estimated) No. of Industries: 2 No. of Occupations: 1 No. of Employees: 34 (estimated) No. of Female Employees: 3 (estimated)

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S36-S36/37/39-S22
RIDADR NONH for all modes of transport
WGK Germany 1
RTECS NS1400000
HS Code 29333999

 Synthetic Route

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Citrazinic acid Structure

Citrazinic acid

CAS#:99-11-6

Literature: EP1801102 A1, ; Page/Page column 9-10 ;

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Citrazinic acid Structure

Citrazinic acid

CAS#:99-11-6

Literature: Chemische Berichte, , vol. 17, p. 2688

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Citrazinic acid Structure

Citrazinic acid

CAS#:99-11-6

Literature: Chemische Berichte, , vol. 17, p. 2688

~%

Citrazinic acid Structure

Citrazinic acid

CAS#:99-11-6

Literature: Chemische Berichte, , vol. 17, p. 2688

~%

Citrazinic acid Structure

Citrazinic acid

CAS#:99-11-6

Literature: Journal of the Chemical Society, , vol. 71, p. 1082 Journal of the Chemical Society, , vol. 73, p. 441

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Citrazinic acid Structure

Citrazinic acid

CAS#:99-11-6

Literature: Journal of the Chemical Society, , vol. 61, p. 1009 Chemische Berichte, , vol. 17, p. 2688

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Citrazinic acid Structure

Citrazinic acid

CAS#:99-11-6

Literature: Journal of the American Pharmaceutical Association (1912-1977), , vol. 45, p. 478

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Citrazinic acid Structure

Citrazinic acid

CAS#:99-11-6

Literature: DE1011885 , ;

 Customs

HS Code 2933399090
Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles2

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J. Org. Chem. 71(12) , 4696-9, (2006)

Although brominated bipyridines and terpyridines are highly desirable synthetic building blocks for both ligand design and macro- or supramolecular applications, few such synthetic precursors have bee...

Synthesis and antimicrobial activity of some new pyrimidinone and oxazinone derivatives fused with thiophene rings using 2-chloro-6-ethoxy-4-acetylpyridine as starting material.

Molecules 17(11) , 13642-55, (2012)

A series of pyridines, pyrimidinones, oxazinones and their derivatives were synthesized as antimicrobial agents using citrazinic acid (2,6-dihydroxyisonicotinic acid) as a starting material. α,β-Unsat...

 Synonyms

2-hydroxy-6-oxo-1H-pyridine-4-carboxylic acid
4-Pyridinecarboxylic acid, 1,2-dihydro-6-hydroxy-2-oxo-
EINECS 202-731-2
6-Hydroxy-4-carboxy-2-pyridone
MFCD00006274
2,6-Dihydroxy-isonicotinic acid
1,2-Dihydro-6-hydroxy-2-oxo-4-pyridinecarboxylic Acid
6-hydroxy-2-oxo-1,2-dihydropyridine-4-carboxylic acid
Citrazinic acid
6-Hydroxy-2-oxo-1,2-dihydro-4-pyridinecarboxylic acid
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