Rotigotine

Suppliers

Names

[ Name ]:
Rotigotine

[Synonym ]:
(S)-ROTIGOTINE
Rotigotine hydrochloride
Rotigotine
(6S)-6-{Propyl[2-(2-thienyl)ethyl]amino}-5,6,7,8-tetrahydro-1-naphthalenol
(6S)-6-{propyl[2-(thiophen-2-yl)ethyl]amino}-5,6,7,8-tetrahydronaphthalen-1-ol
(-)-Rotigotine
1-Naphthalenol, 5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-, (6S)-
(S)-5,6,7,8-TETRAHYDRO-6-(PROPYL(2-(2-THIENYL)ETHYL)AMINO)-1-NAPHTHOL
Neupro

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
470.1±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₉H₂₅NOS

[ Molecular Weight ]:
315.473

[ Flash Point ]:
238.1±28.7 °C

[ Exact Mass ]:
315.165680

[ PSA ]:
51.71000

[ LogP ]:
4.96

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.611

[ Storage condition ]:
room temp

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

(S)-2-(N-n-propyl-N-2-(thien-2-yl)ethylamino)-5-methoxytetraline hydrobromide
Rotigotine Hydrochloride
2-(thiophen-2-yl)ethyl 2-nitrobenzene-1-sulfonate
(-)-(6-PROPYLAMINO)-5,6,7,8-TETRAHYDRO-NAPHTHALEN-1-OL
2-(2-Thienyl)ethyl 4-methylbenzenesulfonate
(S)-5-Methoxy-N-propyl-N-(2-(thiophen-2-yl)ethyl)-1,2,3,4-tetrahydronaphthalen-2-amine
(S)-6-(propyl(2-(thiophen-2-yl)ethyl)amino)-5,6,7,8-tetrahydronaphthalen-1-yl acetate hydrochloride
(S)-6-(propyl(2-(thiophen-2-yl)ethyl)amino)-5,6,7,8-tetrahydronaphthalen-1-yl acetate hydrobromide
2-Thienylacetic acid

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Three-month subchronic intramuscular toxicity study of rotigotine-loaded microspheres in Cynomolgus monkeys.

Food Chem. Toxicol. 52 , 143-52, (2013)

Continuous dopaminergic stimulation (CDS) is an important drug development strategy in the treatment of Parkinson's disease (PD). Rotigotine is a non-ergoline D(3)/D(2)/D(1) dopamine receptor agonist ...

Medication update.

Nurse Pract. 37(6) , 56, (2012)

ADMET considerations for restless leg syndrome drug treatments.

Expert Opin. Drug Metab. Toxicol. 8(10) , 1247-61, (2012)

Restless legs syndrome (RLS) is a common neurological disorder that might impair nocturnal rest causing decreased alertness, depressed mood, reduced job performance, and poor quality of life. In patie...