(rac)-Nebivolol-d8

Modify Date: 2024-01-09 17:32:54

(rac)-Nebivolol-d8 Structure
(rac)-Nebivolol-d8 structure
Common Name (rac)-Nebivolol-d8
CAS Number 1219166-00-3 Molecular Weight 413.48400
Density N/A Boiling Point N/A
Molecular Formula C22H17D8F2NO4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of (rac)-Nebivolol-d8


(Rac)-Nebivolol-d8 ((rac)-R 065824-d8) is a labelled racemic Nebivolol. Nebivolol selectively inhibits β1- adrenergic receptor with IC50 of 0.8 nM[1][2].

 Names

Name rac Nebivolol-d8
Synonym More Synonyms

 (rac)-Nebivolol-d8 Biological Activity

Description (Rac)-Nebivolol-d8 ((rac)-R 065824-d8) is a labelled racemic Nebivolol. Nebivolol selectively inhibits β1- adrenergic receptor with IC50 of 0.8 nM[1][2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Brehm BR, et al. Effects of nebivolol on proliferation and apoptosis of human coronary artery smooth muscle and endothelial cells. Cardiovasc Res. 2001 Feb 1;49(2):430-9.

[3]. Mercanoglu G, et al. The effects of nebivolol on apoptosis in a rat infarct model. Circ J. 2008 Apr;72(4):660-70.

 Chemical & Physical Properties

Molecular Formula C22H17D8F2NO4
Molecular Weight 413.48400
Exact Mass 413.22500
PSA 70.95000
LogP 2.75450

 Synonyms

2-[[2-hydroxy-2-(3,3,4,4-tetradeuterio-6-fluoro-2H-chromen-2-yl)ethyl]amino]-1-(3,3,4,4-tetradeuterio-6-fluoro-2H-chromen-2-yl)ethanol