diethylstilbestrol dipropionate

Modify Date: 2024-01-15 17:02:29

diethylstilbestrol dipropionate structure	Common Name	diethylstilbestrol dipropionate
	CAS Number	130-80-3	Molecular Weight	380.47700
	Density	1.075g/cm3	Boiling Point	486.4ºC at 760mmHg
	Molecular Formula	C₂₄H₂₈O₄	Melting Point	104°
	MSDS	Chinese USA	Flash Point	237ºC
	Symbol	GHS07, GHS08	Signal Word	Danger

Name	diethylstilbestrol dipropionate
Synonym	More Synonyms

Density	1.075g/cm3
Boiling Point	486.4ºC at 760mmHg
Melting Point	104°
Molecular Formula	C₂₄H₂₈O₄
Molecular Weight	380.47700
Flash Point	237ºC
Exact Mass	380.19900
PSA	52.60000
LogP	6.04820
Vapour Pressure	1.29E-09mmHg at 25°C
Index of Refraction	1.542

diethylstilbestrol dipropionate MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WJ5775000

CHEMICAL NAME :: 4,4'-Stilbenediol, alpha,alpha'-diethyl-, dipropionate, (E)-

CAS REGISTRY NUMBER :: 130-80-3

BEILSTEIN REFERENCE NO. :: 2632126

LAST UPDATED :: 199707

DATA ITEMS CITED :: 20

MOLECULAR FORMULA :: C24-H28-O4

MOLECULAR WEIGHT :: 380.52

WISWESSER LINE NOTATION :: 2VOR DY2&UY2&R DOV2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Endocrine - tumors Endocrine - changes in growth hormone

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Implant

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 113 mg/kg

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Endocrine - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Implant

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 5 mg/kg

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Reproductive - Tumorigenic effects - other reproductive system tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 160 mg/kg

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 133 mg/kg/32W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 60 ug/kg

SEX/DURATION :: female 3-4 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - abortion

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 500 ug/kg

SEX/DURATION :: female 5 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 70 ug/kg

SEX/DURATION :: female 28 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 20 ug/kg

SEX/DURATION :: female 3-4 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - abortion

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

DOSE :: 200 ug/kg

SEX/DURATION :: female 13 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 200 ng/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

TYPE OF TEST :: Sex chromosome loss and nondisjunction

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Fibroblast

DOSE/DURATION :: 5 mg/L

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 3,499,1982 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 21,173,1979

Symbol	GHS07, GHS08
Signal Word	Danger
Hazard Statements	H302-H312-H332-H350-H360
Precautionary Statements	P201-P280-P308 + P313
Personal Protective Equipment	Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	T: Toxic;
Risk Phrases	45-46-61-20/21/22
Safety Phrases	S22;S45;S53;S36/S37/S39
RIDADR	UN 3249
WGK Germany	3
RTECS	WJ5775000
Packaging Group	III
Hazard Class	6.1(b)
HS Code	2917399090

HS Code	2917399090
Summary	2917399090 aromatic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Induction of vitellogenesis in Japanese quail as a sensitive indicator of the estrogen-mimetic effect of a variety of environmental contaminants.

Poult. Sci. 63(8) , 1529-36, (1984)

Vitellogenesis was induced in mature male Japanese quail following intramuscular injections of 16 mumol/100 g body weight of any one of four estrogen analogues or 160 mumol/100 g of the nonsteroid zea...

Effect of diethylstilbestrol and related compounds on the Ca(2+)-transporting ATPase of sarcoplasmic reticulum.

J. Biol. Chem. 267(17) , 11923-9, (1992)

Diethylstilbestrol is a potent inhibitory agent of the Ca(2+)-ATPase activity of sarcoplasmic reticulum membranes. Other structurally related molecules, such as dienestrol or hexestrol having hydroxyl...

Follicular growth patterns in the house rat (Rattus rattus).

Eur. J. Morphol. 31(4) , 257-65, (1993)

A histomorphometrical study has been made of the ovarian follicles in the house rat (Rattus rattus) during estrous cycle, pregnancy and after treatment with FSH, LH and estrogen. The relationships bet...

Estroben

Desd

Dibestil

cyrenb

Estilbin

Gynolett

Horfemine

Orestol

EINECS 204-995-4

Euvestin

diethylstilbestrol dipropionate

Names

Chemical & Physical Properties

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

Safety Information

Synthetic Route

Customs

Articles25

Synonyms