LY 292728

Modify Date: 2024-01-27 09:31:25

LY 292728 Structure
LY 292728 structure
Common Name LY 292728
CAS Number 153034-77-6 Molecular Weight 600.58700
Density 1.376g/cm3 Boiling Point 836.6ºC at 760 mmHg
Molecular Formula C34H29FO9 Melting Point N/A
MSDS N/A Flash Point 459.8ºC

 Use of LY 292728


LY 292728 is a potent leukotriene B4 (LTB4) receptor antagonist. LY 292728 binds to human neutrophils with a Ki of 0.47 nM and binds to guinea pig lung membranes with a Ki of 0.04 nM[1].

 Names

Name 5-(2-carboxyethyl)-6-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]-9-oxoxanthene-2-carboxylic acid
Synonym More Synonyms

 LY 292728 Biological Activity

Description LY 292728 is a potent leukotriene B4 (LTB4) receptor antagonist. LY 292728 binds to human neutrophils with a Ki of 0.47 nM and binds to guinea pig lung membranes with a Ki of 0.04 nM[1].
Related Catalog
References

[1]. Sawyer JS, et al. Biphenylyl-substituted xanthones: highly potent leukotriene B4 receptor antagonists. J Med Chem. 1993 Nov 26;36(24):3982-4.  

 Chemical & Physical Properties

Density 1.376g/cm3
Boiling Point 836.6ºC at 760 mmHg
Molecular Formula C34H29FO9
Molecular Weight 600.58700
Flash Point 459.8ºC
Exact Mass 600.18000
PSA 143.50000
LogP 6.58360
Vapour Pressure 1.07E-29mmHg at 25°C
Index of Refraction 1.636

 Synonyms

9h-xanthene-4-propanoic acid,7-carboxy-3-[3-[(5-ethyl-4'-fluoro-2-hydroxy[1,1'-biphenyl]-4-yl)oxy]propoxy]-9-oxo
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