Pelecopan
Modify Date: 2024-01-31 22:36:04
Pelecopan structure
|
Common Name | Pelecopan | ||
|---|---|---|---|---|
| CAS Number | 2378380-49-3 | Molecular Weight | 406.41 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H19FN2O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PelecopanPelecopan (BCX9930) is a potent, selective, orally active inhibitor of complement factor D with an IC50 value of 14.3 nM. Pelecopan can target factor D to prevent both intravascular and extravascular hemolysis in PNH. Pelecopan also be used for other alternative pathway (AP) mediated diseases[1][2]. |
| Name | Pelecopan |
|---|
| Description | Pelecopan (BCX9930) is a potent, selective, orally active inhibitor of complement factor D with an IC50 value of 14.3 nM. Pelecopan can target factor D to prevent both intravascular and extravascular hemolysis in PNH. Pelecopan also be used for other alternative pathway (AP) mediated diseases[1][2]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 14.3 nM (Complement factor D)[1] |
| In Vitro | BCX9930 has a potent, highly specific inhibitory activity for purified human factor D with an IC50 value of 14.3 nM and also inhibits its proteolytic activity against factor B bound to C3b with an IC50 of 28.1 nM. BCX9930 completely blocks hemolysis of PNH cells in vitro (with an IC50 value of 29.5 nM in rabbit erythrocytes) and suppresses the accumulation of C3 fragments on PNH erythrocytes. BCX9930 suppresses AP activity in rhesus monkeys ex vivo assays[1][3]. |
| References |
[1]. International Nonproprietary Names for Pharmaceutical Substances (INN) |
| Molecular Formula | C23H19FN2O4 |
|---|---|
| Molecular Weight | 406.41 |