ZK-90055 (hydrochloride)

Modify Date: 2024-01-05 17:55:04

ZK-90055 (hydrochloride) structure	Common Name	ZK-90055 (hydrochloride)
	CAS Number	84638-81-3	Molecular Weight	342.81800
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₆H₂₃ClN₂O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of ZK-90055 (hydrochloride)

ZK-90055 hydrochloride is a β2 adrenergic receptor agonist.

Name	methyl 4-[2-(tert-butylamino)-1-hydroxyethyl]-7-hydroxy-1H-indole-2-carboxylate,hydrochloride
Synonym	More Synonyms

Description	ZK-90055 hydrochloride is a β2 adrenergic receptor agonist.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Inflammation/Immunology
Target	β2 adrenergic receptor[1]
In Vivo	Contrasting a pro-drug, a soft-drug is active per se when given locally but is rapidly inactivated when it reaches the general circulation. Thus, a long duration of action at a minimum of systemic side effects may be achieved after inhalation of a h2-agonist designed in this way. One such example is ZK-90055, an indol derivative with a hydrolysable ester bond on the ring system. The development of ZK-90055 is stopped before clinical trials are commenced[2].
References	[1]. Waldeck B, et al. beta-Adrenoceptor agonists after terbutaline. Pharmacol Toxicol. 1995;77 Suppl 3:25-9. [2]. Waldeck B, et al. Beta-adrenoceptor agonists and asthma--100 years of development. Eur J Pharmacol. 2002 Jun 7;445(1-2):1-12.

Molecular Formula	C₁₆H₂₃ClN₂O₄
Molecular Weight	342.81800
Exact Mass	342.13500
PSA	94.58000
LogP	3.27450
Storage condition	2-8℃

ZK-90055 (hydrochloride)