Biochemical and Biophysical Research Communications 2015-08-14

Inhibition of invasion by glycogen synthase kinase-3 beta inhibitors through dysregulation of actin re-organisation via down-regulation of WAVE2

Yuki Yoshino, Manami Suzuki, Hidekazu Takahashi, Chikashi Ishioka

文献索引：Biochem. Biophys. Res. Commun. 464 , 275-80, (2015)

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摘要

Cancer cell invasion is a critical phenomenon in cancer pathogenesis. Glycogen synthase kinase-3β (GSK-3β) has been reported to regulate cancer cell invasion both negatively and positively. Thus, the net effect of GSK-3β on invasion is unclear. In this report, we showed that GSK-3β inhibitors induced dysregulation of the actin cytoskeleton and functional insufficiency of focal adhesion, which resulted in suppressed invasion. In addition, WAVE2, an essential molecule for actin fibre branching, was down-regulated after GSK-3β inhibition. Collectively, we propose that the WAVE2-actin cytoskeleton axis is an important target of GSK-3β inhibitors in cancer cell invasion.

相关化合物

  • 氟化钠
  • 蔗糖
  • 氯化钠
  • 十二烷基硫酸钠
  • 2,3-二氨基萘
  • 二甲基亚砜
  • 4-羟乙基哌嗪乙磺酸
  • 氯化钠-35cl
  • 正钒酸钠
  • 钼酸钠

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