氟化钠
一般危化品
氟化钠结构式
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常用名 | 氟化钠 | 英文名 | Sodium Fluoride |
|---|---|---|---|---|
| CAS号 | 7681-49-4 | 分子量 | 41.98820 | |
| 密度 | 1.02 g/mL at 20 °C | 沸点 | 1700 °C | |
| 分子式 | FNa | 熔点 | 993 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 1704°C | |
| 符号 |
GHS06 |
信号词 | Danger |
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Functional consequence of the MET-T1010I polymorphism in breast cancer.
Oncotarget 6(5) , 2604-14, (2015) Major breast cancer predisposition genes, only account for approximately 30% of high-risk breast cancer families and only explain 15% of breast cancer familial relative risk. The HGF growth factor receptor MET is potentially functionally altered due to an unc... |
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Immunomodulation by the Pseudomonas syringae HopZ type III effector family in Arabidopsis.
PLoS ONE 9(12) , e116152, (2014) Pseudomonas syringae employs a type III secretion system to inject 20-30 different type III effector (T3SE) proteins into plant host cells. A major role of T3SEs is to suppress plant immune responses and promote bacterial infection. The YopJ/HopZ acetyltransf... |
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Targeting glucose uptake with siRNA-based nanomedicine for cancer therapy.
Biomaterials 51 , 1-11, (2015) Targeting cancer metabolism is emerging as a successful strategy for cancer therapy. However, most of the marketed anti-metabolism drugs in cancer therapy do not distinguish normal cells from cancer cells, leading to severe side effects. In this study, we rep... |
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Melatonin-mediated Bim up-regulation and cyclooxygenase-2 (COX-2) down-regulation enhances tunicamycin-induced apoptosis in MDA-MB-231 cells.
J. Pineal Res. 58(3) , 310-20, (2015) Melatonin is involved in many physiological functions, and it has differential effects on apoptosis in normal and cancer cells. However, the mechanism of its antitumor roles is not well understood. In this study, we show that melatonin enhances tunicamycin-in... |
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25-O-acetyl-23,24-dihydro-cucurbitacin F induces cell cycle G2/M arrest and apoptosis in human soft tissue sarcoma cells.
J. Ethnopharmacol. 164 , 265-72, (2015) Quisqualis indica is used in traditional Chinese medicine to treat cancer and related syndromes and also known for its anthelminthic effects.Soft tissue sarcomas represent a rare group of malignant tumors that frequently exhibit chemotherapeutic resistance an... |
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G-protein-coupled estrogen receptor 1 is anatomically positioned to modulate synaptic plasticity in the mouse hippocampus.
J. Neurosci. 35(6) , 2384-97, (2015) Both estrous cycle and sex affect the numbers and types of neuronal and glial profiles containing the classical estrogen receptors α and β, and synaptic levels in the rodent dorsal hippocampus. Here, we examined whether the membrane estrogen receptor, G-prote... |
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A small molecule targeting ALK1 prevents Notch cooperativity and inhibits functional angiogenesis.
Angiogenesis 18(2) , 209-17, (2015) Activin receptor-like kinase 1 (ALK1, encoded by the gene ACVRL1) is a type I BMP/TGF-β receptor that mediates signalling in endothelial cells via phosphorylation of SMAD1/5/8. During angiogenesis, sprouting endothelial cells specialise into tip cells and sta... |
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The investigational Aurora kinase A inhibitor alisertib (MLN8237) induces cell cycle G2/M arrest, apoptosis, and autophagy via p38 MAPK and Akt/mTOR signaling pathways in human breast cancer cells.
Drug Des. Devel. Ther. 9 , 1627-52, (2015) Alisertib (ALS) is an investigational potent Aurora A kinase inhibitor currently undergoing clinical trials for the treatment of hematological and non-hematological malignancies. However, its antitumor activity has not been tested in human breast cancer. This... |
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Pro-apoptotic and pro-autophagic effects of the Aurora kinase A inhibitor alisertib (MLN8237) on human osteosarcoma U-2 OS and MG-63 cells through the activation of mitochondria-mediated pathway and inhibition of p38 MAPK/PI3K/Akt/mTOR signaling pathway.
Drug Des. Devel. Ther. 9 , 1555-84, (2015) Osteosarcoma (OS) is the most common malignant bone tumor occurring mostly in children and adolescents between 10 and 20 years of age with poor response to current therapeutics. Alisertib (ALS, MLN8237) is a selective Aurora kinase A inhibitor that displays a... |
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A survey of the interactome of Kaposi's sarcoma-associated herpesvirus ORF45 revealed its binding to viral ORF33 and cellular USP7, resulting in stabilization of ORF33 that is required for production of progeny viruses.
J. Virol. 89(9) , 4918-31, (2015) The ORF45 protein of Kaposi's sarcoma-associated herpesvirus (KSHV) is a gammaherpesvirus-specific immediate-early tegument protein. Our previous studies have revealed its crucial roles in both early and late stages of KSHV infection. In this study, we survey... |