Toxicology Letters 2014-08-17

Fluoride exposure regulates the elongation phase of protein synthesis in cultured Bergmann glia cells.

Marco Flores-Méndez, Diana Ramírez, Nely Alamillo, Luisa C Hernández-Kelly, Luz María Del Razo, Arturo Ortega

文献索引:Toxicol. Lett. 229(1) , 126-33, (2014)

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摘要

Fluoride is an environmental pollutant present in dental products, food, pesticides and water. The latter, is the greatest source of exposure to this contaminant. Structural and functional damages to the central nervous system are present in exposed population. An established consequence of the neuronal is the release of a substantial amount of glutamate to the extracellular space, leading to an excitotoxic insult. Glutamate exerts its actions through the activation of specific plasma membrane receptors and transporters present in neurons and in glia cells and it is the over-activation of glutamate receptors and transporters, the biochemical hallmark of neuronal and oligodendrocyte cell death. In this context, taking into consideration that fluoride leads to degeneration of cerebellar cells, we took the advantage of the well-established model of cerebellar Bergmann glia cultures to gain insight into the molecular mechanisms inherent to fluoride neurotoxicity that might be triggered in glia cells. We could establish that fluoride decreases [(35)S]-methionine incorporation into newly synthesized polypeptides, in a time-dependent manner, and that this halt in protein synthesis is the result of a decrease in the elongation phase of translation, mediated by an augmentation of eukaryotic elongation factor 2 phosphorylation. These results favor the notion of glial cells as targets of fluoride toxicity and strengthen the idea of a critical involvement of glia cells in the function and dysfunction of the brain. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.


相关化合物

  • 氟化钠
  • L-天门冬氨酸
  • 氯化镁
  • L-谷氨酰胺
  • DL-蛋氨酸
  • L-蛋氨酸
  • DL-天门冬氨酸
  • L-天冬氨酸钾

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