Macromolecular Bioscience 2015-07-01

The Role of Charge Density and Hydrophobicity on the Biocidal Properties of Self-Protonable Polymeric Materials.

Simona Matrella, Carmela Vitiello, Massimo Mella, Giovanni Vigliotta, Lorella Izzo

文献索引：Macromol. Biosci. 15 , 927-40, (2015)

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摘要

Intrinsic antimicrobial thermoplastic A(BC)n copolymers (n = 1, 2, 4), where A was poly(ethylene glycol) (PEG), BC was a random chain of methylmethacrylate (MMA), and alkyl-aminoethyl methacrylate (AAEMA), were synthesized and the antimicrobial activity and hemolyticity were evaluated on plaques obtained by casting as a function of the architecture, the N-substituent groups of the AAEMAs (methyl, ethyl, isopropyl, and tert-butyl groups) and the hydrophobic/charge density balance. Antimicrobial effectiveness and efficiency is controlled by the surface charge density and by the influence of N-alkyl groups on the surface morphology. Also interestingly, it is the absence of hemolitytic activity in all copolymers. In presence of Escherichia coli, the A(BC)2 copolymer with 40% of N-methyl groups is the most efficient, killing 91% of the bacteria already after 1.5 h. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

相关化合物

  • 氯仿
  • 乙醇
  • 丙酮
  • 甲醇
  • 二氯甲烷
  • 十六烷基三甲基氯化...
  • 吡啶
  • 甲苯
  • 对甲苯磺酸一水合物
  • 4-二甲氨基吡啶

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